SML0922

NSC130813

≥98% (HPLC)

• 동의어(들): 4-[(6-Chloro-2-methoxy-9-acridinyl)amino]-2-[(4-methyl-1-piperazinyl)methyl]-phenol trihydrochloride, F06, NERI02
• 실험식(Hill 표기법): C₂₆H₂₇ClN₄O₂ · 3HCl
• CAS Number: 1082532-95-3
• Molecular Weight: 572.35
• UNSPSC 코드: 51111800
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: yellow to orange
• solubility: H₂O: 10 mg/mL, clear
• 저장 온도: −20°C

설명

생화학적/생리학적 작용

NSC130813 blocks protein-protein interactions between XPF and ERCC1, two proteins involved in nucleotide excision repair (NER). The compound, NSC130813, blocks repair of DNA damage induced by platinum-based ctyotoxic drugs and DNA alkylating agents. NSC130813 synergistically potentiates cell death in cancer cell lines treated with cisplatin or mitomycin C.

NSC130813 is a Xeroderma Pigmentosa Group F (XPF) antagonist, inhibitor of nucleotide excision repair (NER) mechanism.

기타 정보

air sensitive

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable