SML0198

Fenoldopam mesylate

≥98% (HPLC)

• 동의어(들): Fenoldopam methanesulfonate
• 실험식(Hill 표기법): C₁₆H₁₆ClNO₃ · CH₄O₃S
• CAS Number: 67227-57-0
• Molecular Weight: 401.86
• EC Number: 266-612-7
• MDL number: MFCD04112986
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825223
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• 색상: white to tan
• mp: 271 °C (lit.)
• solubility: DMSO: ≥15 mg/mL at ~60 °C
• 저장 온도: room temp
• SMILES string: CS(O)(=O)=O.Oc1ccc(cc1)C2CNCCc3c(Cl)c(O)c(O)cc23
• InChI: 1S/C16H16ClNO3.CH4O3S/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21;1-5(2,3)4/h1-4,7,13,18-21H,5-6,8H2;1H3,(H,2,3,4)
• InChI key: CVKUMNRCIJMVAR-UHFFFAOYSA-N
• 유전자 정보: human ... DRD1(1812)

설명

애플리케이션

Fenoldopam mesylate may be used to study dopamine D₁-mediated cell signaling.

생화학적/생리학적 작용

Dopamine D1-receptor agonist; Antihypertensive

Fenoldopam mesylate (FM) is considered as an effective therapeutic agent to prevent the onset of postoperative AKI (PO-AKI). In healthy cats, FM can stimulate diuresis and be well-tolerated. This benzazepine-derivative is regional specific and does not cause cerebral vasodilation.

Fenoldopam mesylate is a selective dopamine D₁ receptor agonist used as an antihypertensive agent. It is an agonist for D₁-like dopamine receptors and binds with moderate affinity to α2-adrenoceptors. It has no significant affinity for D₂-like receptors, α1 and α-adrenoceptors, 5HT₁ and 5HT₂ receptors, or muscarinic receptors. Fenoldopam mesylate causes peripheral vasodilation by stimulating dopamine-1receptors and α2-adrenoceptors, increasing renal blood flow.

특징 및 장점

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302,H317,H319
• 예방조치 성명서: P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable