SML0681

Febrifugine dihydrochloride

≥95% (HPLC)

• 동의어(들): 3-[3-[(2R,3S)-3-Hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone dihydrochloride
• 실험식(Hill 표기법): C₁₆H₁₉N₃O₃ · 2HCl
• CAS Number: 32434-42-7
• Molecular Weight: 374.26
• UNSPSC 코드: 51111800
• PubChem Substance ID: 329825583
• NACRES: NA.77

속성

• 분석: ≥95% (HPLC)
• 형태: powder
• 광학 활성: [α]/D 10 to 15°, c = 1 in H₂O
• 저장 조건: desiccated
• 색상: off-white to gray-brown
• solubility: H₂O: 15 mg/mL, clear
• 저장 온도: −20°C
• SMILES string: O=C1C2=CC=CC=C2N=CN1CC(C[C@@H]3[C@@H](O)CCCC3)=O.C
• InChI: 1S/C17H20N2O3.CH4/c20-13(9-12-5-1-4-8-16(12)21)10-19-11-18-15-7-3-2-6-14(15)17(19)22;/h2-3,6-7,11-12,16,21H,1,4-5,8-10H2;1H4/t12-,16+;/m1./s1
• InChI key: SNTOTCUGCWLHEZ-KKJWGQAZSA-N

설명

생화학적/생리학적 작용

Febrifugine dihydrochloride exhibits strong antimalarial activity against Plasmodium falciparum, the most insidious malaria causative agent. The adverse effects of febrifugine include diarrhoea, vomiting and liver toxicity.

Febrifugine is an antimalarial, the active component of the Chinese herb Chang Shan. Recent studies indicate that its mechanism of action is as an inhibitor of prolyl-transfer RNA synthetase (ProRS).

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable