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Merck
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주요 문서

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SML0444

Sigma-Aldrich

Pluripotin

≥98% (HPLC)

동의어(들):

N-[3-[7-(2,5-Dimethyl-2H-pyrazol-3-ylamino)-1-methyl-2-oxo-1,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-3-yl]-4-methylphenyl]-3-trifluoromethyl-benzamide, SC 1, SC-1

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C27H25F3N8O2
CAS Number:
839707-37-8
Molecular Weight:
550.54
MDL number:
MFCD20527253
UNSPSC 코드:
12352200
PubChem Substance ID:
329824726
NACRES:
NA.77

분석

≥98% (HPLC)

양식

powder

색상

white to beige

solubility

DMSO: 10 mg/mL (clear solution)

저장 온도

−20°C

SMILES string

CN1C(=O)N(Cc2cnc(Nc3cc(C)nn3C)nc12)c4cc(NC(=O)c5cccc(c5)C(F)(F)F)ccc4C

InChI

1S/C27H25F3N8O2/c1-15-8-9-20(32-24(39)17-6-5-7-19(11-17)27(28,29)30)12-21(15)38-14-18-13-31-25(34-23(18)36(3)26(38)40)33-22-10-16(2)35-37(22)4/h5-13H,14H2,1-4H3,(H,32,39)(H,31,33,34)

InChI key

NBZFRTJWEIHFPF-UHFFFAOYSA-N

생화학적/생리학적 작용

Pluripotin is an activator of murine embryonic stem (ES) cell renewal; Dual RasGAP and ERK1 inhibitor.
Pluripotin is an activator of murine embryonic stem (ES) cell self-renewal. It appears that pluripotin mediates the activity by dual RasGAP and ERK1 inhibition.

특징 및 장점

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number
082M4717V

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문서

MAPKs

The mitogen-activated protein kinase (MAPK) family consists of both stress activated (SAPK) and mitogen-activated (MAPK) protein kinases. They form a network of signal transduction cascades that mediate cellular responses to a diverse range of stimuli, including growth factors, chemical or osmotic stress, irradiation, bacterial infection and proinflammatory cytokines.

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