SML0320

FR180204

≥98% (HPLC)

• 동의어(들): 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine, 5-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-amine, FR 180204
• 실험식(Hill 표기법): C₁₈H₁₃N₇
• CAS Number: 865362-74-9
• Molecular Weight: 327.34
• MDL number: MFCD14585805
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825325
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: faintly yellow to dark yellow
• solubility: DMSO: ≥10 mg/mL
• 저장 온도: 2-8°C
• SMILES string: Nc1n[nH]c2nnc(cc12)-c3c(nn4ccccc34)-c5ccccc5
• InChI: 1S/C18H13N7/c19-17-12-10-13(20-22-18(12)23-21-17)15-14-8-4-5-9-25(14)24-16(15)11-6-2-1-3-7-11/h1-10H,(H3,19,21,22,23)
• InChI key: XVECMUKVOMUNLE-UHFFFAOYSA-N

설명

애플리케이션

FR180204 has been used as ERK inhibitor:

• to block extracellular-signal-regulated kinase (ERK) in order to validate whether homeobox B7 (HOXB7) regulates the migration and proliferation process via AKT/mitogen-activated protein kinases (MAPK) signaling
• of extracellular-signal-regulated kinase (ERK) to study the effects of signaling pathway inhibitors on differentiation and cell traction stress
• to determine if phosphorylation of this signaling protein is essential for mesenchymal stromal cell (MSC) derived therapeutic efficacy

생화학적/생리학적 작용

FR180204 is a potent, cell-permeable, ATP-competitive inhibitor of ERK1 and ERK2 (mitogen-activated protein kinase (MAPK)/extracellular-signal-regulated kinases (ERK) 1/2).

FR180204 is a potent, selective, cell-permeable, ATP-competitive inhibitor of ERK1 and ERK2.

It can be used to study the roles of ERK as well as for drug development.

특징 및 장점

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable