SML0372

NSC23925

≥98% (HPLC)

• 동의어(들): 2-(p-Methoxyphenyl)-α-2-piperidyl-4-quinolinemethanol dihydrochloride, NSC-23925, [2-(4-Methoxyphenyl)4-quinolinyl]-(piperidin-2-y)-methanol dihydrochloride
• 실험식(Hill 표기법): C₂₂H₂₄N₂O₂ · 2HCl
• CAS Number: 858474-14-3
• Molecular Weight: 421.36
• MDL number: MFCD22666390
• UNSPSC 코드: 12161501
• PubChem Substance ID: 329825373
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• 색상: white to beige
• solubility: H₂O: 5 mg/mL (clear solution)
• 저장 온도: room temp
• SMILES string: Cl.Cl.COc1ccc(cc1)-c2cc(C(O)C3CCCCN3)c4ccccc4n2
• InChI: 1S/C22H24N2O2.2ClH/c1-26-16-11-9-15(10-12-16)21-14-18(17-6-2-3-7-19(17)24-21)22(25)20-8-4-5-13-23-20;;/h2-3,6-7,9-12,14,20,22-23,25H,4-5,8,13H2,1H3;2*1H
• InChI key: WGWOQHWZXLGPNG-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

NSC23925 is a specific Pgp1 inhibitor. It reverses MDR1 (Pgp1) but does not inhibit MRP or BCRP-mediated MDR. NSC23925 itself is not a substrate of Pgp1 but stimulates ATPase activity of Pgp, directly inhibiting the function of Pgp1 in a dose-dependent manner without altering the total expression level of Pgp1.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301
• 예방조치 성명서: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable