SML0246
Tirofiban hydrochloride monohydrate
≥98% (HPLC)
동의어(들):
L 700462, MK 383, N-(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-L-tyrosine
로그인조직 및 계약 가격 보기
모든 사진(1)
About This Item
실험식(Hill 표기법):
C22H36N2O5S·HCl·H2O
CAS Number:
Molecular Weight:
495.07
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
광학 활성
[α]/D -10 to -18° (c=1, MeOH)
저장 조건
desiccated
색상
white to beige
solubility
DMSO: >12 mg/mL at warmed to 60 °C
배송 상태
wet ice
저장 온도
−20°C
SMILES string
OC([C@@H](NS(CCCC)(=O)=O)CC1=CC=C(C=C1)OCCCCC2CCNCC2)=O.Cl.O
InChI
1S/C22H36N2O5S.ClH.H2O/c1-2-3-16-30(27,28)24-21(22(25)26)17-19-7-9-20(10-8-19)29-15-5-4-6-18-11-13-23-14-12-18;;/h7-10,18,21,23-24H,2-6,11-17H2,1H3,(H,25,26);1H;1H2/t21-;;/m0../s1
InChI key
HWAAPJPFZPHHBC-FGJQBABTSA-N
유전자 정보
human ... ITGA2B(3674) , ITGB3(3690)
애플리케이션
Tirofiban hydrochloride monohydrate has been used as an αIIbβ3 integrin (glycoprotein IIb/IIIa) inhibitor for mouse induced pluripotent stem cell (iPSC) culture.
생화학적/생리학적 작용
Tirofiban hydrochloride is a potent non-peptide, glycoprotein IIb/IIIa inhibitor. Blocks platelet aggregation and thrombus formation.
Tirofiban might cause thrombocytopenia.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Yu-Lun Tseng et al.
Toxicology and applied pharmacology, 364, 106-113 (2018-12-29)
Collagen and convulxin induce platelet aggregation through glycoprotein VI (GPVI)-FcRγ-Syk signaling pathway. In addition, fibrinogen induces platelet activation through integrin αIIbβ3-FcγRIIa-Syk signaling pathway. We previously reported that high concentrations of selective serotonin reuptake inhibitors (SSRI) reduce platelet aggregation induced by
Xia Hong et al.
Journal of clinical laboratory analysis, 30(2), 108-113 (2014-11-27)
Activated clotting time (ACT) has been successfully applied during percutaneous coronary intervention (PCI) to monitor the extent of thrombin inhibition and anti-coagulation from unfractionated heparin (UFH) aiming to reduce the incidence of thrombotic adverse events and hemorrhagic complications. And this
Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions (2015)
Inhibition of the integrin signal constitutes a mouse iPS cell niche.
Higuchi S, et al.
Development, Growth & Differentiation, 58(7), 586-599 (2016)
C J Panebianco et al.
European cells & materials, 39, 211-226 (2020-05-13)
Back pain is a leading cause of global disability associated with intervertebral disc (IVD) pathologies. Discectomy alleviates disabling pain caused by IVD herniation without repairing annulus fibrosus (AF) defects, which can cause accelerated degeneration and recurrent pain. Biological therapies show
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.