SMB00287

Formycin A

from Streptomyces kaniharaensis, ≥98% (HPLC)

• 동의어(들): 1-C-(7-Amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-(1S)-D-Ribitol, 7-Amino-3-(β-D-ribofuranosyl)-1H-pyrazolo[4,3-d]pyrimidine, 8-Aza-9-deazaadenosine, Formycin, NSC 102811
• 실험식(Hill 표기법): C₁₀H₁₃N₅O₄
• CAS Number: 6742-12-7
• Molecular Weight: 267.24
• Beilstein: 624229
• MDL number: MFCD00036807
• UNSPSC 코드: 51102829
• PubChem Substance ID: 329824924
• NACRES: NA.85

속성

• 생물학적 소스: Streptomyces kaniharaensis
• Quality Level: 200
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: (Keep container tightly closed in a dry and well-ventilated place.)
• 색상: white to off-white
• solubility: DMSO: soluble 1 mg/mL; H₂O: soluble 3 mg/mL
• 항생제 활성 스펙트럼: viruses (Antiretroviral)
• 동작 모드: enzyme | inhibits
• 저장 온도: −20°C
• SMILES string: Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
• InChI: 1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
• InChI key: OIRDTQYFTABQOQ-KQYNXXCUSA-N
• 유전자 정보: human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140)

설명

일반 설명

Chemical structure: nucleoside

Formycin A is an adenosine analog, and is cytotoxic in nature. It acts as a substrate for the human enzymes human erythrocytic adenosine deaminase and adenosine kinase.

생화학적/생리학적 작용

Formycin A (FA) is a C-nucleoside that inhibits the E.coli enzyme purine nucleoside phosphorylase (PNP).

Formycin A (FA) is a C-nucleoside that inhibits the E.coli enzyme purine nucleoside phosphorylase (PNP). FA was found to upsurge insulin release elevated by glucose, and was also shown to inhibit 5′-Methylthioadenosine/S-adenosylhomocysteine (MTA/AdoHcy) nucleosidase, an enzyme important in the recycling of methionine. Research has shown FA is an antiretroviral agent against HIV-1, targeting reverse transcription.

Formycin A possess antitumor function, along with its antibacterial and antiviral activity.

포장

10MG

기타 정보

Keep container tightly closed in a dry and well-ventilated place.

Store the product sealed at –20 °C. Under these conditions the product is stable for at least 4 years.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable