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Merck
모든 사진(1)

Key Documents

SAE0066

Sigma-Aldrich

Adenylyl Cyclase Toxin from Bordetella pertussis

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About This Item

UNSPSC 코드:
12352200
NACRES:
NA.26

생물학적 소스

Bordetella pertussis Tohama I

Quality Level

분석

≥70%

형태

liquid

특이 활성도

≥ 50  units/mg protein

기술

cell culture | mammalian: suitable

적합성

suitable for molecular biology

응용 분야

detection

저장 온도

−20°C

유전자 정보

Bordetella pertussis Tohama I ... CyaA(69600712)

일반 설명

Research area: IMMUNO AND CKS

Adenylate Cyclase Toxin (ACT or CyaA) is a member of the extensive family of toxins known as Repeat in Toxin (RTX), which are produced by Gram-negative organisms. ACT is encoded by the cyaA gene and secreted extracellularly in the form of a soluble protein. It exhibits both adenylate cyclase enzymatic activity and hemolytic activity. The synthesis, maturation, and secretion of ACT are regulated by the CyaCABD operon. Moreover, its specific cellular receptor, CD11b/CD18 integrin (αMβ2, Mac-1, or CR3), is expressed on myeloid phagocytes.

애플리케이션

Adenylyl Cyclase Toxin from Bordetella pertussis has been used as Gα(i/o) inhibitor to study the involvement of the sphingosine 1-phosphate receptor 2/Gα(12/13)/MAPK signaling pathway in the priming and activation of NLRP3 inflammasome during cholestatic liver injury.

생화학적/생리학적 작용

Adenylate Cyclase Toxin (CyaA) is responsible for inhibiting the phagocytic activities of neutrophils and macrophages by impairing oxidative response and chemotaxis, ultimately leading to cell apoptosis or necrosis. Additionally, ACT can upregulate the expression of MHC class II and costimulatory molecules on dendritic cells, thereby reducing proinflammatory cytokine production.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

Lei Hou et al.
Journal of molecular medicine (Berlin, Germany), 99(2), 273-288 (2021-01-04)
NLRP3 inflammasome-driven inflammation represents a key trigger for hepatic fibrogenesis during cholestatic liver injury. However, whether sphingosine 1-phosphate (S1P) plays a role in NLRP3 inflammasome priming and activation remains unknown. Here, we found that the expression of NLRP3 in macrophages
Yao Wei et al.
Nature communications, 11(1), 941-941 (2020-02-20)
Oxidative stress is a major pathogenic mechanism in Parkinson's disease (PD). As an important cellular antioxidant, glutathione (GSH) balances the production and incorporation of free radicals to protect neurons from oxidative damage. GSH level is decreased in the brains of

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