SAB5700569

Anti-Phospho-ABL1-Y412 antibody produced in rabbit

• 동의어(들): ABL, ABL1, CHDSKM, JTK7, bcr/abl, c-ABL, c-ABL1, c-Abl, p150, v-abl
• UNSPSC 코드: 12352203

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: 123
• 종 반응성: rat, mouse, human
• 농도: 0.51mg/ml
• 기술: immunohistochemistry: 1:50-1:200; western blot: 1:500-1:2000
• UniProt 수납 번호: P00519
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: phosphorylation (pTyr412)
• 유전자 정보: human ... ABL1 (25)

설명

일반 설명

This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5′ end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.

면역원

A phospho synthetic peptide corresponding to residues surrounding Y412 of human ABL1.

물리적 형태

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

저장 및 안정성

Store at -20℃. Avoid freeze / thaw cycles.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable