추천 제품
생물학적 소스
mouse
Quality Level
결합
unconjugated
항체 형태
purified immunoglobulin
항체 생산 유형
primary antibodies
클론
S114-10, monoclonal
형태
buffered aqueous glycerol solution
분자량
antigen predicted mol wt 130 kDa
종 반응성
rat, human, mouse
농도
1 mg/mL
기술
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
동형
IgG1
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
rat ... HCN4(59266)
일반 설명
Hyperpolarization activated cyclic nucleotide-gated potassium channel 4 (HCN4) is one of the subunits of hyperpolarization-activated cyclic nucleotide-gated channels, which have a role in synaptic transmission, dendritic integration, membrane and action potential. It is a heteromeric channel. HCN4 is highly expressed in rat embryonic hearts, specifically in the sinoatrial node.
특이성
Detects ~130 kDa. No cross-reactivity against other HCNs
면역원
Fusion protein amino acids 1019-1198 (c-terminus) of rat HCN4, Accession Number Q9JKA7
특징 및 장점
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물리적 형태
Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Jianlin Du et al.
Acta biochimica et biophysica Sinica, 49(5), 400-408 (2017-04-04)
The activity of pacemaker cells in the sinoatrial node (SAN) is an indicator of normal sinus rhythm. Clinical studies have revealed that the dysfunction of the SAN progressively increases with aging. In this study, we determined the changes in hyperpolarization-activated
Valentina Prando et al.
The Journal of physiology, 596(11), 2055-2075 (2018-03-11)
The present study demonstrates, by in vitro and in vivo analyses, the novel concept that signal transmission between sympathetic neurons and the heart, underlying the physiological regulation of cardiac function, operates in a quasi-synaptic fashion. This is a result of
Associated changes in HCN2 and HCN4 transcripts and I(f) pacemaker current in myocytes.
Zhang Q
Biochimica et Biophysica Acta (2009)
Lubov B Mitrofanova et al.
Journal of cellular and molecular medicine, 22(1), 521-532 (2017-11-18)
The sinoatrial node (SAN) is composed mostly of pacemaker, transitional and Purkinje-like cells. Pacemaker cells, especially in the centre of the SAN, are surrounded by dense fibrous tissue and do not have any contact with transitional cells. We hypothesize that
Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel.
Milanesi R
The New England Journal of Medicine (2006)
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