추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
antigen 33 kDa
종 반응성
mouse, human, rat
농도
~1 mg/mL
기술
ELISA: 1:5000
western blot: 1:500-1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
phosphorylation (pTyr15)
유전자 정보
human ... CDK5(1020)
일반 설명
Cyclin-dependent kinase 5 (CDK5) belongs to the CDKs family. Active CDK5 is present in pancreatic β cells, corneal epithelial cells and monocytes. This gene is mapped to human chromosome 7q36.
면역원
The antiserum was produced against synthesized peptide derived from human CDK5 around the phosphorylation site of Tyr15.
Immunogen Range: 1-50
Immunogen Range: 1-50
생화학적/생리학적 작용
Cyclin-dependent kinase 5 (CDK5) controls migration and neuronal plasticity. This protein participates in neuron migration, neurite outgrowth and support and synaptogenesis. It also helps in the development of lymphatic vessels. Suppressing Cdk5 promotes cell death of tumor-initiating cells.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Evaluation and clinical significance of cyclin-dependent kinase5 expression in cervical lesions: a clinical research study in Guangxi, China
Pan DH, et al.
European Journal of Medical Research, 21(1), 28-28 (2016)
Cyclin-dependent kinase 5 controls vasculogenic mimicry formation in non-small cell lung cancer via the FAK-AKT signaling pathway
Zhou X, et al.
Biochemical and Biophysical Research Communications, 492(3), 447-452 (2017)
Inhibition of Cdk5 induces cell death of tumor-initiating cells
Mandl MM, et al.
British Journal of Cancer, 116(7), 912-922 (2017)
Biological functions of CDK5 and potential CDK5 targeted clinical treatments
Shupp A, et al.
Oncotarget, 8(10), 17373-17382 (2017)
Chia-Yi Su et al.
Scientific reports, 9(1), 13703-13703 (2019-09-25)
Cyclin-dependent kinase 5 (Cdk5) is predominantly expressed in neuron and plays an important role in neuronal physiology. Increasing evidence also indicates that Cdk5 may contribute to malignant progression of some types of cancers; however, the underlying mechanism remains elusive. In
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