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Merck
모든 사진(8)

주요 문서

SAB4503779

Sigma-Aldrich

Anti-phospho-Smad1 (pSer465) antibody produced in rabbit

affinity isolated antibody

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

rabbit

Quality Level

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

양식

buffered aqueous solution

분자량

antigen 52 kDa

종 반응성

mouse, rat, human

농도

~1 mg/mL

기술

ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI 수납 번호

UniProt 수납 번호

배송 상태

wet ice

저장 온도

−20°C

타겟 번역 후 변형

phosphorylation (pSer465)

유전자 정보

human ... SMAD1(4086)

일반 설명

Smad1 (SMAD family member 1) is a transcriptional activator, that is located on human chromosome 4q31.

면역원

The antiserum was produced against synthesized peptide derived from human Smad1 around the phosphorylation site of Ser465.

Immunogen Range: 416-465

생화학적/생리학적 작용

SMAD (homologues of the Drosophila protein, mothers against decapentaplegic (Mad) and the Caenorhabditis elegans protein Sma) proteins have a major role in disease development and hence act as biologic prognostic factors in diseases. miR-345 represses the multiplication, invasion and migration of prostate cancer by downregulating Smad1.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

The distribution and potential prognostic value of SMAD protein expression in chronic lymphocytic leukemia.
Witkowska M, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 39(3), 1010428317694551-1010428317694551 (2017)
Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal
Fuentealba LC, et al.
Cell, 131(5), 980-993 (2007)
An interstitial 4q31.21q31.22 microdeletion associated with developmental delay: case report and literature review
Vlaikou AM, et al.
Cytogenetic and genome research, 142(4), 227-238 (2014)
MiR-345 suppresses proliferation, migration and invasion by targeting Smad1 in human prostate cancer
Chen QG, et al.
Journal of Cancer Research and Clinical Oncology, 142(1), 213-224 (2016)
Marina Peralta et al.
Cell reports, 32(3), 107932-107932 (2020-07-23)
Cilia and the intraflagellar transport (IFT) proteins involved in ciliogenesis are associated with congenital heart diseases (CHDs). However, the molecular links between cilia, IFT proteins, and cardiogenesis are yet to be established. Using a combination of biochemistry, genetics, and live-imaging

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