SAB4501880

Anti-KI67 antibody produced in rabbit

affinity isolated antibody

• 동의어(들): Antigen KI-67, MKI67
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: antigen 358 kDa
• 종 반응성: human
• 농도: ~1 mg/mL
• 기술: ELISA: 1:10000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100
• NCBI 수납 번호: P46013
• UniProt 수납 번호: P46013
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... MKI67(4288)

설명

일반 설명

Marker of proliferation Ki-67 (MKI67) is encoded by the gene mapped to human chromosome 10. The encoded protein is characterized by the phosphopeptide-binding forkhead-associated (FHA) domain and a protein phosphatase 1 (PP1)-binding site at N- terminal, 16 tandem repeats at central region and leucine and arginine (LR) pairs at C- terminal end.

면역원

The antiserum was produced against synthesized peptide derived from human Ki67.

Immunogen Range: 3207-3256

애플리케이션

Anti-KI67, C-Terminal antibody produced in rabbit has been used in following studies:

• immunohistochemistry.
• immunofluorescence staining.
• western blotting

생화학적/생리학적 작용

Marker of proliferation Ki-67 (MKI67), which is a part of the mitotic chromosome periphery, function as a biological surfactant to maintain individual mitotic chromosomes dispersed in the cytoplasm after nuclear envelope disassembly. Ki-67 is a vital prognostic marker in breast and prostate cancer. Expression of the encoded protein is associated with cell-proliferation rate. Ki-67 is expressed at all active phases of the cell cycle (G (1), S, G (2), and mitosis), except resting cells (G (0)). Therefore, this protein is considered as a potential cell proliferation marker.

특징 및 장점

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물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable