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Merck
모든 사진(2)

Key Documents

SAB4501063

Sigma-Aldrich

Anti-GABBR1 antibody produced in rabbit

affinity isolated antibody

동의어(들):

γ-aminobutyric acid type B receptor subunit 1, GABA-B receptor 1, GABA-B-R1, GABBR1, Gb1

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

rabbit

Quality Level

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

형태

buffered aqueous solution

분자량

antigen 108 kDa

종 반응성

mouse, human, rat

농도

~1 mg/mL

기술

ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI 수납 번호

UniProt 수납 번호

배송 상태

wet ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... GABBR1(2550)

관련 카테고리

일반 설명

Anti-GABBR1 Antibody detects endogenous levels of total GABBR1 protein.
The γ-aminobutyric acid type B (GABAB) receptor is coded by the GABBR1 gene. It has 22 exons and spans at least 18 kb. GABAB geneis present between an olfactory receptor gene cluster downstream and the HLA (human leukocyte antigen) class I region upstream. It is mapped to human chromosome 6p22.

면역원

The antiserum was produced against synthesized peptide derived from human GABBR1.

Immunogen Range: 891-940

생화학적/생리학적 작용

The γ-aminobutyric acid type B (GABAB) is essential for the initiation by agonists like GABA (gamma-aminobutyric acid ). GABAB receptors participates in response habituation. In the visual cortex, GABAB is also involved in the initiation of orientation tuning in conjunction with GABAA receptors.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

GABBR1 has a HERV-W LTR in its regulatory region?a possible implication for schizophrenia.
Hegyi H.
Biology Direct, 8(1), 5-5 (2013)
Association between Single Nucleotide Polymorphisms in Gamma-Aminobutyric Acid B Receptor, Insulin Receptor Substrate-1, and Hypocretin Neuropeptide Precursor Genes and Susceptibility to Obstructive Sleep Apnea Hypopnea Syndrome in a Chinese Han Population.
Li Z, et al.
Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre, 25(6), 517-524 (2016)
Different roles for GABAA and GABAB receptors in visual processing in the rat superior colliculus.
Binns KE and Salt TE
The Journal of Physiology, 504(3), 629-639 (1997)
GABBR 1 and SLC 6A1, Two Genes Involved in Modulation of GABA Synaptic Transmission, Influence Risk for Alcoholism: Results from Three Ethnically Diverse Populations.
Enoch MA, et al.
Alcoholism, Clinical and Experimental Research, 40(1), 93-101 (2016)

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