추천 제품
생물학적 소스
mouse
Quality Level
항체 형태
purified from hybridoma cell culture
항체 생산 유형
primary antibodies
클론
MANDYS8, monoclonal
양식
buffered aqueous solution
분자량
~427 kDa
종 반응성
porcine, rabbit, mouse, rat, human
향상된 검증
independent
Learn more about Antibody Enhanced Validation
농도
~1.0 mg/mL
기술
immunoblotting: suitable
immunohistochemistry: 5-10 μg/mL using acetone fixed rat tongue frozen sections
동형
IgG2b
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... DMD(1756)
일반 설명
Anti-Dystrophin antibody, Mouse monoclonal (mouse IgG2b isotype) is derived from the MANDYS8 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from mouse immunized with fragment of recombinant human dystrophin. Dystrophin is a 427 kD protein which joins the actin cytoskeleton to laminin. It possesses multiple domains and is localized to the extracellular matrix. Dystrophin contains NH2-terminal domain for actin binding. The C-terminal domain interacts with dystrophin associated protein (DAP).
Dystrophin is a rod-shaped cytoskeletal protein located to the periphery (plasma membrane) of normal striated muscle fibers.
특이성
Anti-Dystrophin antibody, Mouse monoclonal specifically recognizes an epitope located on the rod domain of the human dystrophin molecule.
면역원
recombinant human dystrophin
애플리케이션
Anti-Dystrophin antibody, Mouse monoclonal has been used in immunoblotting and immunohistochemistry.
생화학적/생리학적 작용
Dystrophin is known to prevent muscle fibre injury due to contraction.
물리적 형태
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as preservative.
기타 정보
This product is for R&D use only, not for drug, household, or other uses.
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Storage Class Code
12 - Non Combustible Liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Anna Cho et al.
Muscle & nerve, 55(5), 727-734 (2016-09-07)
Duchenne and Becker muscular dystrophies (DMD and BMD) are allelic X-linked recessive muscle diseases caused by mutations in the large and complex dystrophin gene. We analyzed the dystrophin gene in 507 Korean DMD/BMD patients by multiple ligation-dependent probe amplification and
Assembly of the dystrophin-associated protein complex does not require the dystrophin COOH-terminal domain
Crawford GF, et al.
The Journal of Cell Biology, 150(6), 1399-1410 (2000)
Applications of CRISPR technologies in research and beyond
Barrangou R and Doudna JA
Nature Biotechnology, 34(9), 933-933 (2016)
Immunofluorescence microscopy of SNAP23 in human skeletal muscle reveals colocalization with plasma membrane, lipid droplets, and mitochondria
Strauss JA, et al.
Physiological Reports, 4(1), e12662-e12662 (2016)
Juliette A Strauss et al.
Physiological reports, 4(1) (2016-01-07)
Synaptosomal-associated protein 23 (SNAP23) is a SNARE protein expressed abundantly in human skeletal muscle. Its established role is to mediate insulin-stimulated docking and fusion of glucose transporter 4 (GLUT4) with the plasma membrane. Recent in vitro research has proposed that SNAP23
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