SAB4200574

Anti-Claudin-4 (C-terminal) antibody produced in rabbit

affinity isolated antibody

• 동의어(들): (CPER), CLDN4, CPE-R, CPETR1, Clostridium, Williams-Beuren syndrome chromosomal region 8(WBSCR8), enterotoxin, hCPE-R, perfringens, receptor
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 200
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 종 반응성: rat, human, canine
• 기술: immunoblotting: suitable; immunofluorescence: suitable; immunohistochemistry: suitable
• UniProt 수납 번호: P01275
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... CLDN4(1364)

설명

일반 설명

Claudin-4 is heterogeneously expressed in various tissues. It is enriched in endothelial cells (ECs), including the blood-brain barrier, and is also expressed in gut and kidney. It is mapped to human chromosome 7q11.23. Claudin-4 is associated with the tight junction strands in kidney epithelial cells.

특이성

Anti-Claudin-4 (C-terminal) specifically recognizes human, rat and dog claudin-4.

애플리케이션

Anti-Claudin-4 (C-terminal) antibody produced in rabbit has been used in:

• immunoblotting
• immunofluorescence
• immunohistochemistry

생화학적/생리학적 작용

Claudin-4 is involved in maintaining cellular polarity. It favors sodium chloride absorption and acts as a cation-barrier. Claudin-4 expression has been shown to be deregulated in several cancers, with aberrant expression in ovarian, breast, prostate and pancreatic carcinomas. The gene location of claudin-4 is a Williams-Beuren syndrome critical region.

물리적 형태

Supplied as a solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

저장 및 안정성

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable