추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
predicted mol wt 54 kDa
종 반응성
human, mouse, rat
기술
ELISA: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable
NCBI 수납 번호
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... SLC39A14(23516)
일반 설명
Solute carrier family 39 member 14 or Zrt- and Irt-like protein 14 (ZIP14), a transmembrane metal ion transporter, is a member of the LIV-1 subfamily. It contains eight transmembrane domains (TMDs), a metalloprotease, and a histidine-rich motif. ZIP14 is majorly expressed in the pancreas, liver, and heart. The ZIP14 gene is mapped to human chromosome 8p21.3.
면역원
ZIP14 antibody was raised against a 16 amino acid peptide near the center of human ZIP14.
애플리케이션
Anti-ZIP14 antibody produced in rabbit has been used in immunoblotting. 1:2500
생화학적/생리학적 작용
Zrt- and Irt-like protein 14 (ZIP14) is a divalent metal transporter specific for zinc (Zn). However, some studies report, it also mediates the transport of manganese (Mn), iron (Fe), and cadmium (Cd). ZIP14 along with ZIP8 are prime Mn2+ importers of the brain′s capillary bed and in human brain microvascular endothelial cells (HBMVEC) in in vitro conditions. Mutations in the ZIP14 gene lead to manganese dyshomeostasis, which in turn results in manganese accumulation in childhood-onset parkinsonism–dystonia patients.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
결합
The action of this antibody can be blocked using blocking peptide SBP3500603.
물리적 형태
Supplied in PBS with 0.02% sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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관련 제품
Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia.
Karin Tuschl et al.
Nature communications, 7, 11601-11601 (2016-05-28)
Although manganese is an essential trace metal, little is known about its transport and homeostatic regulation. Here we have identified a cohort of patients with a novel autosomal recessive manganese transporter defect caused by mutations in SLC39A14. Excessive accumulation of
Lisa J Routhe et al.
Glia, 68(9), 1810-1823 (2020-02-23)
Neurodegeneration is associated with inflammation and mismanaged iron homeostasis, leading to increased concentration of non-transferrin-bound iron (NTBI) in the brain. NTBI can be taken up by cells expressing Zrt-, Irt-like protein-14 (ZIP14), which is regulated by iron overload and pro-inflammatory
Brittany L Steimle et al.
The Journal of biological chemistry, 294(50), 19197-19208 (2019-11-09)
Manganese supports numerous neuronal functions but in excess is neurotoxic. Consequently, regulation of manganese flux at the blood-brain barrier (BBB) is critical to brain homeostasis. However, the molecular pathways supporting the transcellular trafficking of divalent manganese ions within the microvascular
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