추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
종 반응성
human, mouse
기술
immunocytochemistry: suitable
indirect ELISA: suitable
western blot: suitable
NCBI 수납 번호
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... C1QTNF6(114904)
일반 설명
C1q and TNF (Tumour necrosis factor) related protein 6 (CTRP6/C1QTNF6) is a glycoprotein which belongs to family of proteins containing TNF alpha-like globular domain. CTRP6 is a single peptide with a short variable region, a collagen like region, and a C-terminal globular domain. CTRP6 is expressed in human synoviocytes. In human chromosome, the gene is localized on 22q12.3.
면역원
CTRP6 antibody was raised against a 15 amino acid peptide from near the carboxy-terminus of human CTRP6.
생화학적/생리학적 작용
C1q and TNF (Tumour necrosis factor) related protein 6 (CTRP6) plays a major role in fatty acid metabolism. CTRP6 phosphorylates AMCK (5′-AMP (adenosine monophosphate)-activated protein kinase) and ACC (acetyl coenzyme A carboxylase) and activates AMCK-ACC pathway. The expression level of CTRP6 is increased in rheumatoid arthritis. CTRP6 inhibits alternative complement pathway and helps in maintaining pregnancy. CTRP6 mediates the ectopic lipogenesis in myoblasts through AdipoR1/Erk/PPARγ (Adiponectin receptor 1/Extracellular signal-regulated kinases/Peroxisome proliferator-activated receptor gamma) signalling pathway. CTRP6 is overexpressed in hepatocellular carcinoma and stimulates angiogenesis by Akt (serine/threonine-protein kinase) pathway. CTRP6 confers susceptibility to type I diabetes. CTRP6 maybe a key regulator connecting obesity with tissue inflammation and insulin resistance.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
결합
The action of this antibody can be blocked using blocking peptide SBP3500196.
물리적 형태
Supplied in PBS with 0.02% sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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관련 제품
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
C1q/TNF-related protein 6 (CTRP6) links obesity to adipose tissue inflammation and insulin resistance
Lei X, et al.
The Journal of Biological Chemistry, 292(36), 14836-14850 (2017)
Lipogenesis in myoblasts and its regulation of CTRP6 by AdipoR1/Erk/PPAR gamma signalling pathway
Wu W, et al.
Acta biochimica et biophysica Sinica, 48(6), 509-519 (2016)
Expression of a secretory protein C1qTNF6, a C1qTNF family member, in hepatocellular carcinoma
Takeuchi T, et al.
Analytical Cellular Pathology, 34(3), 113-121 (2011)
Masanori A Murayama et al.
Nature communications, 6, 8483-8483 (2015-09-26)
The complement system is important for the host defence against infection as well as for the development of inflammatory diseases. Here we show that C1q/TNF-related protein 6 (CTRP6; gene symbol C1qtnf6) expression is elevated in mouse rheumatoid arthritis (RA) models.
Wan Lee et al.
FEBS letters, 584(5), 968-972 (2010-01-28)
C1qTNF-related proteins (CTRPs) are involved in diverse processes including metabolism, inflammation host defense, apoptosis, cell differentiation, autoimmunity, hibernation, and organogenesis. However, the physiological role of CTRP6 remains poorly understood. Here we demonstrate that the globular domain of CTRP6 mediates the
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