SAB2702364

Monoclonal Anti-Iba1 antibody produced in mouse

clone GT10312, affinity isolated antibody

• 동의어(들): AIF-1, IBA1, IRT-1, IRT1
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: GT10312, monoclonal
• 양식: buffered aqueous solution
• 분자량: 17kDa
• 종 반응성: mouse, human, rat
• 농도: 2.03mg/mL
• 기술: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:1000; indirect immunofluorescence: suitable; western blot: 500-3000
• 동형: IgG1
• UniProt 수납 번호: P55008
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... AIF1(199)

설명

일반 설명

Ionized calcium-binding adapter molecule 1 (IBA1), also called the allograft inflammatory factor 1 (AIF1) is mapped to human chromosome 6p21.33. It encodes a 17 kDa protein and comprises calcium binding EF hand motif. IBA1 is expressed in lung, tonsil, lymph node and spleen. In addition,it is also expressed in macrophages and glial cells.

면역원

Recombinant protein encompassing a sequence within the center region of human Iba1.

애플리케이션

Monoclonal Anti-Iba1 antibody produced in mouse has been used:

• in the double immunofluorescence
• in the immunofluorescence
• in immunohistochemistry

생화학적/생리학적 작용

Ionized calcium-binding adapter molecule 1 (IBA1) interacts with filamentous actin (F‐actin) and L‐fimbrin. Its expression is modulated during injury. Inflammatory cytokines also induce IBA1 expression. IBA1 expression is implicated in the graft rejection in coronary artery vasculopathy (CAV). It is highly expressed in hepatocellular carcinoma and may serve a potential marker and therapeutic target. Increased expression of AIF1 in synovial fluid and peripheral blood monocytes is implicated in rheumatoid arthritis.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

기타 정보

Purification: Affinity purified by Protein G

물리적 형태

Phosphate-buffered saline, no preservative added.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable