추천 제품
생물학적 소스
mouse
Quality Level
항체 형태
IgG fraction of antiserum
항체 생산 유형
primary antibodies
클론
9E10, monoclonal
양식
buffered aqueous solution
기술
western blot: 1:2,000
동형
IgG1
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
일반 설명
The cellular myelocytomatosis (c-myc) gene is mapped to human chromosome 8q24. It is the cellular homologue of the v-myc gene originally isolated from an avian myelocytomatosis virus. c-myc is a member of MYC gene family.c-Myc gene codes for basic helix-loop-helix/leucine zipper (bHLH/LZ) transcription factor that regulates the G1-S cell cycle transition.
애플리케이션
MONOCLONAL ANTI-MYC TAG antibody produced in mouse has been used in Western blotting.
생화학적/생리학적 작용
The cellular myelocytomatosis (c-myc) oncogene plays a vital role in cellular proliferation, differentiation, apoptosis and acts as transcriptional regulator of gene expression. c-myc expression is essential and sufficient to assist most of the cells to enter DNA synthetic (S) phase of the cell cycle. The encoded protein plays a crucial role in vasculogenesis and angiogenesis during cancer development and progression. c-myc interacts with its binding partner Max and activates the transcription of growth promoting genes such as cyclin D2 and ornithine decarboxylase. It also represses the transcription of multiple genes, especially p21 and p27, by binding to the transcription initiator element (Inr) in a complex with Max and either Sp1 or Miz1. Overexpression of MYC in DLBCL (diffuse large B-cell lymphoma) results in poor outcome and invasive treatment when medicated with rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP).
물리적 형태
Supplied in PBS with 0.09% (W/V) sodium azide
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
Long noncoding RNA MALAT1 promotes hepatic steatosis and insulin resistance by increasing nuclear SREBP-1c protein stability
Caifeng Yan, et al.
Scientific Reports (2016)
Over-expression of the c-myc proto-oncogene in colorectal carcinoma.
Smith DR, et al.
British Journal of Cancer, 68(2) (1993)
Zixing Li et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(19), E4522-E4531 (2018-04-25)
Abscisic acid (ABA) plays essential roles in plant development and responses to environmental stress. ABA induces subcellular translocation and degradation of the guanine nucleotide exchange factor RopGEF1, thus facilitating ABA core signal transduction. However, the underlying mechanisms for ABA-triggered RopGEF1
MAPK signal pathways in the regulation of cell proliferation in mammalian cells.
Zhang W, et al.
Cell Research, 12(1), 9-18 (2002)
HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity.
Gordan JD,et al.
Cancer Cell, 11(4), 335-347 (2007)
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