S8688

SR 59230A

≥98% (HPLC), powder, β3-Adrenoceptor antagonist

• 동의어(들): 3-(2-Ethylphenoxy)-1-[[(1S)-1,2,3,4-tetrahydronaphth-1-yl]amino]-(2S)-2-propanol oxalate salt
• 실험식(Hill 표기법): C₂₁H₂₇NO₂ · C₂H₂O₄
• CAS Number: 174689-39-5
• Molecular Weight: 415.48
• MDL number: MFCD00940163
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278715
• NACRES: NA.77

속성

• product name: SR 59230A, ≥98% (HPLC), powder
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: powder
• 색상: white
• solubility: DMSO: >10 mg/mL; H₂O: insoluble
• 주관자: Sanofi Aventis
• SMILES string: OC(=O)C(O)=O.CCc1ccccc1OC[C@@H](O)CN[C@H]2CCCc3ccccc23
• InChI: 1S/C21H27NO2.C2H2O4/c1-2-16-8-4-6-13-21(16)24-15-18(23)14-22-20-12-7-10-17-9-3-5-11-19(17)20;3-1(4)2(5)6/h3-6,8-9,11,13,18,20,22-23H,2,7,10,12,14-15H2,1H3;(H,3,4)(H,5,6)/t18-,20-;/m0./s1
• InChI key: XTBQNQMNFXNGLR-MKSBGGEFSA-N
• 유전자 정보: human ... ADRB3(155)

설명

애플리케이션

SR 59230A was used in the identification of β-adrenoceptors in rat aorta.³ It was tested as a potential therapeutic agent in improving cardiac function in rat model of heart failure.⁴

생화학적/생리학적 작용

SR 59230A is a β3-adrenoceptor antagonist. It has high affinity for the β3 adrenoceptors occurring in human gut that affect the function of human colonic circular smooth muscle.¹ It is reported that SR 59230A inhibits the Kir2.1-2.3 cardiac potassium channels.²

특징 및 장점

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)