A8727
Antalarmin hydrochloride
≥98% (HPLC), solid, CRF1 antagonist
동의어(들):
N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolol[2,3-d]pyrimidin-4-amine hydrochloride
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C24H34N4·HCl
CAS Number:
Molecular Weight:
415.01
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
제품명
Antalarmin hydrochloride, ≥98% (HPLC), solid
Quality Level
분석
≥98% (HPLC)
양식
solid
저장 조건
desiccated
색상
off-white
solubility
DMSO: >10 mg/mL
저장 온도
2-8°C
SMILES string
Cl[H].CCCCN(CC)c1nc(C)nc2n(c(C)c(C)c12)-c3c(C)cc(C)cc3C
InChI
1S/C24H34N4.ClH/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5;/h13-14H,9-12H2,1-8H3;1H
InChI key
CGDGXEDXEXACKQ-UHFFFAOYSA-N
애플리케이션
Antalarmin hydrochloride has been used:
- to study its effect on stress-induced tryptophan hydroxylase 2 activity
- to study the anxiogenic effects of corticotropin-releasing factor 1 (CRF1) activation
- to analyze the therapeutic effect of blocking corticotrophin-releasing hormone (CRH) signaling in treating social stress-induced depression
Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist.
생화학적/생리학적 작용
Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist.
Antalarmin serves as a non steroidal inhibitor of pregnancy even during the early stages. It is known to delay parturition. It also prevents the development of gastric ulcers which arises in response to stress.
특징 및 장점
This compound is featured on the Corticotropin-Releasing Factor Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
Deficits in KCC2 and activation of the HPA axis lead to depression-like behavior following social defeat
Miller S and Maguire J
Hormonal Studies, 2(1), 2-2 (2014)
Eric P Zorrilla et al.
Brain research, 952(2), 188-199 (2002-10-12)
Molecular studies point to a role for the type 1 corticotropin-releasing factor receptor (CRF(1)) in anxiogenic-like and activating effects of CRF and stress. However, CP-154,526, a selective CRF(1) antagonist, has yielded mixed results in such tests. Few studies have examined
Nancy K Mello et al.
Pharmacology, biochemistry, and behavior, 85(4), 744-751 (2006-12-22)
Cocaine stimulates the rapid release of ACTH, and by inference, CRF in several species, suggesting that the HPA "stress" axis may contribute to the abuse-related effects of cocaine. The effects of a systemically-active CRF(1) receptor antagonist, antalarmin, on cocaine self-administration
Anna Skórzewska et al.
Stress (Amsterdam, Netherlands), 22(1), 113-122 (2018-10-23)
This study aimed to test the hypothesis that high-anxiety (HR) rats are more sensitive to the effects of chronic corticosterone administration and antalarmin (corticotropin-releasing factor (CRF) receptor 1, CRF1 antagonist) injections than low-anxiety (LR) rats, and this effect is accompanied
CRF type 1 receptors of the medial amygdala modulate inhibitory avoidance responses in the elevated T-maze
Vicentini JE, et al.
Hormones and Behavior, 65(3), 195-202 (2014)
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