RAB0326

C-Peptide EIA Kit

for serum, plasma, culture supernatant and cell lysates

• 동의어(들): C-Peptide
• UNSPSC 코드: 41116158
• NACRES: NA.32

속성

• 종 반응성: human, mouse, rat
• 포장: kit of 96 wells (12 strips x 8 wells)
• 기술: ELISA: suitable; enzyme immunoassay: suitable
• 입력: sample type plasma; sample type cell lysate; sample type culture supernatant(s); sample type serum
• assay range: inter-assay cv: <15%; intra-assay cv: <10%; sensitivity: 772 pg/mL; standard curve range: 0.1-1000 ng/mL
• 검출 방법: colorimetric
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... INS(3630)

설명

일반 설명

The C-Peptide Enzyme Immunoassay (EIA) Kit is an in vitro quantitative assay for detecting C-Peptide peptide based on the principle of Competitive Enzyme Immunoassay. EIA-CPE-1 only detects C-peptide, not Insulin A or B chain.

면역원

C-Peptide , synthetic peptide

애플리케이션

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

생화학적/생리학적 작용

C-peptide inhibits endothelial dysfunction under high glucose conditions via inhibition of nuclear factor-κB (NF-κB) pathway. Experimental studies suggest that prolonged dosage of physiological concentration of C-peptide to type 1 diabetes patients minimizes diabetes-induced complications, such as glomerular hypertrophy and mesangial matrix expansion by interrupting transforming growth factor β1 (TGF-β1) and tumor necrosis factor α (TNFα) signaling pathway. C-peptide reduces diabetes-induced glomerular hyperfiltration by contraction of the afferent arteriole, dilation of the efferent arteriole, and by inhibition of tubular reabsorption. C-Peptide also plays a crucial role in renal pathophysiology. C-peptide binds to a cell surface receptor that is likely to be G-protein coupled. This interaction stimulates various cellular functions such as increasing intracellular Ca²⁺ concentration, enhancing PI3-K (phosphoinositide 3-kinase) activity, increased endothelial nitric oxide synthase (eNOS) transcription, and activation of the Na⁺/K⁺ ATPase and mitogen-activated protein kinase (MAPK) signaling pathway.

키트 구성품 역시 별도로 이용 가능함

• RABHRP3 HRP-Streptavidin

안전성 정보

• 픽토그램: GHS05
• 신호어: Warning
• 유해 및 위험 성명서: H290
• 예방조치 성명서: P234 - P390
• Hazard Classifications: Met. Corr. 1
• Storage Class Code: 8A - Combustible corrosive hazardous materials