Q0875

Quinidine sulfate salt dihydrate

• 실험식(Hill 표기법): C₄₀H₄₈N₄O₄ · H₂O₄S · 2H₂O
• CAS Number: 6591-63-5
• Molecular Weight: 782.94
• EC Number: 200-046-3
• MDL number: MFCD00149346
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24277870
• NACRES: NA.77

속성

• 불순물: ≤20% Dihydroquinidine (according to USP specifications., actual content given on label)
• mp: 212-214 °C (dec.) (lit.)
• 주관자: Bayer
• SMILES string: [H]O[H].[H]O[H].OS(O)(=O)=O.[H][C@]1(CN2CCC1C[C@]2([H])[C@@H](O)c3ccnc4ccc(OC)cc34)C=C.[H][C@]5(CN6CCC5C[C@]6([H])[C@@H](O)c7ccnc8ccc(OC)cc78)C=C
• InChI: 1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14?,19-,20+;;;/m11.../s1
• InChI key: ZHNFLHYOFXQIOW-WFTMRWCJSA-N

설명

일반 설명

Quinidine is an alkaloid present in the bark of the Cinchona tree. It is the D-isomer of quinine, an antimalarial drug.

애플리케이션

Quinidine sulfate salt dihydrate has been used as an antiarrhythmic drug to study its effects on phosphorylation and mutations in the cardiac sodium channel Nav1.5.

생화학적/생리학적 작용

Quinidine shows therapeutic effects against atrial fibrillation and cardiac arrhythmias.

Class IA antiarrhythmic; potassium channel blocker.

특징 및 장점

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves