P8765

Ammonium pyrrolidinedithiocarbamate

~99%

• 동의어(들): 1-Pyrrolidinecarbodithioic acid ammonium salt, APDC, Ammonium pyrrolidinecarbodithioate, PDC, PDTC
• Linear Formula: C₅H₉NS₂ · NH₃
• CAS Number: 5108-96-3
• Molecular Weight: 164.29
• Beilstein: 3730472
• EC Number: 225-834-4
• MDL number: MFCD00012720
• UNSPSC 코드: 12352107
• PubChem Substance ID: 24278658
• NACRES: NA.77

속성

• 생물학적 소스: microbial
• 분석: ~99%
• 양식: (powderor powder with lumps)
• mp: 153-155 °C (lit.)
• solubility: water: 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
• 저장 온도: 2-8°C
• SMILES string: N.SC(=S)N1CCCC1
• InChI: 1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3
• InChI key: MDDIUTVUBYEEEM-UHFFFAOYSA-N
• 유전자 정보: human ... NOS1(4842) , NOS2(4843) , NOS2B(201288) , NOS2C(645740) , NOS3(4846) , RELA(5970)

설명

일반 설명

Ammonium pyrrolidinedithiocarbamate is a nuclear factor κB (NF-κB) inhibitor. It functions as a chelating agent, which allows the preconcentration of trace metals from solution. Pyrrolidinedithiocarbamate (PDTC) has antioxidant properties. It inhibits apoptosis in lymphocytes, neurons and vascular endothelial cells.

애플리케이션

Ammonium pyrrolidinedithiocarbamate has been used:

• to inhibit nuclear factor κB (NF-κB) mobilization and TNF (tumor necrosis factor) production in human monocytes
• to reduce neutrophil activity in rats
• to prevent Ca²⁺ influx in adriamycin (ADR)-treated podocytes

to abrogate the microRNA-146a promoter luciferase reporter activity in human brain cells

생화학적/생리학적 작용

Prevents induction of nitric oxide synthetase by inhibiting translation of NOS mRNA; induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves