추천 제품
Quality Level
분석
≥98% (HPLC)
형태
solid
저장 조건
protect from light
색상
off-white to gray-pink
solubility
DMSO: >10 mg/mL
배송 상태
wet ice
저장 온도
−20°C
InChI
1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3
InChI key
YMFNPBSZFWXMAD-UHFFFAOYSA-N
애플리케이션
JSH-23 has been used as a nuclear factor κB (NF-κB) p65 inhibitor.
생화학적/생리학적 작용
JSH-23 is an inhibitor of NF-kB nuclear translocation. It inhibits LPS and cytokine-induced nuclear translocation of the p65 subunit of NF-kB as analyzed by EMSA and western blot. The compound displays modest potency (IC50 7.1 uM in RAW 264.7), but has the unique property that it does not affect IkB degradation or recovery. The compound dose dependently inhibits LPS induced expression of cytokines, COX2 and iNOS, and presumably binds to, or interferes with the NLS of p65.
기타 정보
Light and air sensitive.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Macrophage TCF-4 co-activates p65 to potentiate chronic inflammation and insulin resistance in mice.
Kang X et al.
Clinical Science (London, England : 1979), 130, 1257-1257 (2016)
HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-?B pathway in acute glaucoma.
Chi W et al.
Journal of Neuroinflammation, 12, 137-137 (2015)
L Shi et al.
Oncogene, 36(12), 1631-1643 (2016-11-22)
The coordination between cellular differentiation and the mesenchymal/stem transition is essential for both embryo development and neoplasia, suggesting a mechanistic link between these two major processes. In this work we show that miR-127, an embryo-expressing lung miRNA, was prominently induced
Macrophage TCF-4 co-activates p65 to potentiate chronic inflammation and insulin resistance in mice.
Xia Kang et al.
Clinical science (London, England : 1979), 130(14), 1257-1268 (2016-04-30)
Transcription factor 4 (TCF-4) was recently identified as a candidate gene for the cause of type 2 diabetes, although the mechanisms have not been fully elucidated. In the present study, we demonstrated that the TCF-4 transgene in macrophages aggravated high-fat diet
Meibao Feng et al.
Molecular cancer, 15(1), 77-77 (2016-12-04)
Lipocalin2 (LCN2) is a secretory protein that is aberrantly expressed in several types of cancer and has been involved in metastatic progression. However, neither mechanisms nor the role that LCN2 plays in the metastasis of colorectal cancer are clear. LCN2
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.