P4670

Propafenone hydrochloride

• 동의어(들): 1-[2-(2-Hydroxy-3-(propylamino)propoxy)phenyl]-3-phenyl-1-propanone hydrochloride
• 실험식(Hill 표기법): C₂₁H₂₇NO₃ · HCl
• CAS Number: 34183-22-7
• Molecular Weight: 377.90
• EC Number: 251-867-9
• MDL number: MFCD00079243
• UNSPSC 코드: 41116107
• PubChem Substance ID: 24278636
• NACRES: NA.77

속성

• 형태: powder
• Quality Level: 100
• 주관자: Abbott
• 저장 온도: 2-8°C
• SMILES string: Cl[H].CCCNCC(O)COc1ccccc1C(=O)CCc2ccccc2
• InChI: 1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H
• InChI key: XWIHRGFIPXWGEF-UHFFFAOYSA-N
• 유전자 정보: human ... ABCB1(5243) , ADRB1(153) , ADRB2(154) , ADRB3(155) , CYP1A2(1544) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

설명

일반 설명

Propafenone hydrochloride is a calcium antagonist. It functions as a Na⁺ and K⁺ channel blocker. It might be used to treat patients with systemic hypertension. Propafenone hydrochloride is associated with bradycardia and bronchospasms. It is metabolized in the liver. Propafenone hydrochloride is used to treat ventricular arrhythmias.

애플리케이션

Propafenone hydrochloride has been used in the isolation of cardiomyocytes.

생화학적/생리학적 작용

Blocks hKv1.5 and ATP-sensitive K⁺ channels; class 1C antiarrhythmic agent that is also an antagonist at β adrenergic receptors.

특징 및 장점

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3