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Merck
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P3657

Sigma-Aldrich

Pyridoxal 5′-phosphate hydrate

powder, BioReagent, suitable for cell culture

동의어(들):

3-Hydroxy-2-methyl-5-([phosphonooxy]methyl)-4-pyridinecarboxaldehyde, Codecarboxylase, PLP, Pyridoxal 5-phosphate

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모든 사진(2)

About This Item

실험식(Hill 표기법):
C8H10NO6P · xH2O
CAS Number:
853645-22-4
Molecular Weight:
247.14 (anhydrous basis)
Beilstein:
234749
EC Number:
200-208-3
MDL number:
MFCD00006333
UNSPSC 코드:
12352205
PubChem Substance ID:
24898438
NACRES:
NA.75

제품 라인

BioReagent

분석

≥98%

양식

powder

분자량

Mw 247.14 g/mol

기술

cell culture | mammalian: suitable

색상

off-white to yellow-brown

mp

140-143 °C

solubility

1 M HCl: soluble 50 mg/mL, clear, colorless to light yellow-green

저장 온도

−20°C

SMILES string

CC1=NC=C(COP(O)(O)=O)C(C([H])=O)=C1O

InChI

1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)

InChI key

NGVDGCNFYWLIFO-UHFFFAOYSA-N

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일반 설명

Pyridoxal-phosphate (PLP, pyridoxal-5′-phosphate, P5P) is a prosthetic group of some enzymes. It is the active form of vitamin B6, which comprises three natural organic compounds, pyridoxal, pyridoxamine and pyridoxine. PLP acts as a coenzyme in all transamination reactions, and in some decarboxylation and deamination reactions of amino acids.

애플리케이션


  • Hierarchical Surface Architecture of Hemodialysis Membranes for Eliminating Homocysteine Based on the Multifunctional Role of Pyridoxal 5′-phosphate.: Discusses the development of advanced hemodialysis membranes using pyridoxal 5′-phosphate, highlighting its role in reducing homocysteine levels, which could contribute to improved outcomes for dialysis patients (Jiang P et al., 2020).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number
SLCK7246
SLCD6819
SLBZ7499
SLBP7347V
SLBM9225V

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COA 검색

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문서 라이브러리 방문

Ivone Carvalho et al.
Bioorganic & medicinal chemistry, 18(7), 2412-2427 (2010-03-26)
Trypanosoma cruzi trans-sialidase (TcTS) plays a key role in the recognition and invasion of host cells and in enabling the parasite to escape the human immune response. To explore this potential drug target, we have synthesized a small library of
Jennifer H Richens et al.
Biology open, 4(8), 1052-1061 (2015-07-15)
Centrosomes comprise a pair of centrioles surrounded by a matrix of pericentriolar material (PCM). In vertebrate cells, Pericentrin plays an important part in mitotic PCM assembly, but the Drosophila Pericentrin-like protein (PLP) appears to have a more minor role in
Trina Das et al.
The Journal of general virology, 96(Pt 2), 294-310 (2014-10-30)
Chikungunya virus (CHIKV) has recently affected millions of people in the Indian Ocean, with rare cases of encephalopathy and encephalitis occurring in neonates. In the study described herein, the capacity of mouse brain cells to control infection through innate immune
Bogdan F G Popescu et al.
Neurology, 84(2), 148-158 (2014-12-17)
To assess, in a surgical biopsy cohort of active demyelinating lesions, the diagnostic utility of aquaporin-4 (AQP4) immunohistochemistry in identifying neuromyelitis optica (NMO) or NMO spectrum disorder (NMOSD) and describe pathologic features that should prompt AQP4 immunohistochemical analysis and AQP4-immunoglobulin
Alexandros K Kanellopoulos et al.
Cell, 180(6), 1178-1197 (2020-03-24)
Social impairment is frequently associated with mitochondrial dysfunction and altered neurotransmission. Although mitochondrial function is crucial for brain homeostasis, it remains unknown whether mitochondrial disruption contributes to social behavioral deficits. Here, we show that Drosophila mutants in the homolog of
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문서

Vitamin B6, Pyridoxal and Pyridoxine in Cell Culture

This page segues to comprehensive insights on how Vitamin B6, Pyridoxal and Pyridoxine affect the performance of serum-free, protein-free cell culture systems used for biomanufacturing heterologous proteins including monoclonal antibodies. The page introduces the in vitro chemistry and biochemistry of pyridoxal, pyridoxine.

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