추천 제품
생물학적 소스
synthetic
Quality Level
분석
≥97.0% (NT)
양식
powder
기술
enzyme immunoassay: suitable
색상
white to light yellow
mp
140-143 °C (lit.)
음이온 미량물
chloride (Cl-): ≤500 mg/kg
sulfate (SO42-): ≤50 mg/kg
양이온 미량물
Ca: ≤20 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤50 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤2000 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg
응용 분야
cell analysis
저장 온도
2-8°C
SMILES string
O=CC1=C(C(C)=NC=C1COP(O)(O)=O)O.[OH]
InChI
1S/C8H10NO6P.H2O/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14;/h2-3,11H,4H2,1H3,(H2,12,13,14);1H2
InChI key
CEEQUQSGVRRXQI-UHFFFAOYSA-N
일반 설명
Pyridoxal 5′-phosphate (PLP), an active form of vitamin B6/ pyridoxine is the coenzyme of amino acid metabolism.
애플리케이션
Pyridoxal 5′-phosphate monohydrate has been used:
- as a component in the reaction mixture for ornithine decarboxylase (ODC) activity assay
- as a standard to quantify the concentration of pyridoxal 5′-phosphate (PLP) in cerebrospinal fluid (CSF) of children
- as a dietary supplement to study its effects on the lethal phenotype of mutant flies
생화학적/생리학적 작용
Pyridoxine participates in the production of lipid and neurotransmitters. Pyridoxal 5′-phosphate (PLP) serves as a cofactor to stabilize carbanions at Cα of amino acids. Pyridoxine deficiency results in peripheral neuropathy. Absence of PLP leads to neonatal epileptic encephalopathy. PLP acts as a coenzyme in transamination, decarboxylation and deamination reactions such as the conversion of dopa into dopamine; of glutamate into γ aminobutyric acid (GABA); of histidine to histamine. PLP works mechanistically through formation of a Schiff-base.
기타 정보
Coenzymes and Cofactors, vol. 1: Vitamin B6, Pyridoxal Phosphate
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
이미 열람한 고객
Protein science : a publication of the Protein Society, 20(9), 1492-1508 (2011-06-29)
Sphingolipids are membrane constituents as well as signaling molecules involved in many essential cellular processes. Serine palmitoyltransferase (SPT) and sphingosine-1-phosphate lyase (SPL), both PLP (pyridoxal 5'-phosphate)-dependent enzymes, function as entry and exit gates of the sphingolipid metabolism. SPT catalyzes the
Chemical, Biochemical and Medical Aspects, 792-792 null
Nutritional Deficiencies and Syndromes Associated with Alcoholism
Textbook of Clinical Neurology, 897-917 (2007)
Assay of Ornithine Decarboxylase and Spermidine/Spermine N1-acetyltransferase Activities
Bio-protocol (2014)
Regulation and function of pyridoxal phosphate in CNS
Neurochemistry International, 3(3-4), 207-209 (1981)
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