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Merck
모든 사진(1)

주요 문서

82870

Sigma-Aldrich

Pyridoxal 5′-phosphate monohydrate

≥97.0% (NT)

동의어(들):

P5P, 3-Hydroxy-2-methyl-5-([phosphonooxy]methyl)-4-pyridinecarboxaldehyde, Codecarboxylase, PLP, Pyridoxal 5-phosphate

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About This Item

실험식(Hill 표기법):
C8H10NO6P · H2O
CAS Number:
Molecular Weight:
265.16
Beilstein:
234749
MDL number:
UNSPSC 코드:
12352204
PubChem Substance ID:
NACRES:
NA.51

생물학적 소스

synthetic

Quality Level

분석

≥97.0% (NT)

양식

powder

기술

enzyme immunoassay: suitable

색상

white to light yellow

mp

140-143 °C (lit.)

음이온 미량물

chloride (Cl-): ≤500 mg/kg
sulfate (SO42-): ≤50 mg/kg

양이온 미량물

Ca: ≤20 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤50 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤2000 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

응용 분야

cell analysis

저장 온도

2-8°C

SMILES string

O=CC1=C(C(C)=NC=C1COP(O)(O)=O)O.[OH]

InChI

1S/C8H10NO6P.H2O/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14;/h2-3,11H,4H2,1H3,(H2,12,13,14);1H2

InChI key

CEEQUQSGVRRXQI-UHFFFAOYSA-N

일반 설명

Pyridoxal 5′-phosphate (PLP), an active form of vitamin B6/ pyridoxine is the coenzyme of amino acid metabolism.

애플리케이션

Pyridoxal 5′-phosphate monohydrate has been used:
  • as a component in the reaction mixture for ornithine decarboxylase (ODC) activity assay
  • as a standard to quantify the concentration of pyridoxal 5′-phosphate (PLP) in cerebrospinal fluid (CSF) of children
  • as a dietary supplement to study its effects on the lethal phenotype of mutant flies

생화학적/생리학적 작용

Pyridoxine participates in the production of lipid and neurotransmitters. Pyridoxal 5′-phosphate (PLP) serves as a cofactor to stabilize carbanions at Cα of amino acids. Pyridoxine deficiency results in peripheral neuropathy. Absence of PLP leads to neonatal epileptic encephalopathy. PLP acts as a coenzyme in transamination, decarboxylation and deamination reactions such as the conversion of dopa into dopamine; of glutamate into γ aminobutyric acid (GABA); of histidine to histamine. PLP works mechanistically through formation of a Schiff-base.

기타 정보

Coenzymes and Cofactors, vol. 1: Vitamin B6, Pyridoxal Phosphate

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Florence Bourquin et al.
Protein science : a publication of the Protein Society, 20(9), 1492-1508 (2011-06-29)
Sphingolipids are membrane constituents as well as signaling molecules involved in many essential cellular processes. Serine palmitoyltransferase (SPT) and sphingosine-1-phosphate lyase (SPL), both PLP (pyridoxal 5'-phosphate)-dependent enzymes, function as entry and exit gates of the sphingolipid metabolism. SPT catalyzes the
Chemical, Biochemical and Medical Aspects, 792-792 null
Nutritional Deficiencies and Syndromes Associated with Alcoholism
Textbook of Clinical Neurology, 897-917 (2007)
Assay of Ornithine Decarboxylase and Spermidine/Spermine N1-acetyltransferase Activities
Hyvonen MT, et al.
Bio-protocol (2014)
Regulation and function of pyridoxal phosphate in CNS
Metzler DE
Neurochemistry International, 3(3-4), 207-209 (1981)

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