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Merck
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주요 문서

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D1415

Sigma-Aldrich

4,6-Dioxoheptanoic acid

powder

동의어(들):

Succinylacetone

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모든 사진(4)

About This Item

Linear Formula:
CH3COCH2COCH2CH2CO2H
CAS Number:
51568-18-4
Molecular Weight:
158.15
MDL number:
MFCD00002797
UNSPSC 코드:
12352211
PubChem Substance ID:
24893433
NACRES:
NA.25

양식

powder

Quality Level

200

mp

66-67 °C (lit.)

지질 유형

saturated FAs

저장 온도

2-8°C

SMILES string

CC(=O)CC(=O)CCC(O)=O

InChI

1S/C7H10O4/c1-5(8)4-6(9)2-3-7(10)11/h2-4H2,1H3,(H,10,11)

InChI key

WYEPBHZLDUPIOD-UHFFFAOYSA-N

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애플리케이션

4,6-Dioxoheptanoic acid has been used:
  • as component of dendritic cell conditioning medium and in the inhibition of ALA dehydratase (ALAD) in dendritic cells(50)
  • as an inhibitor of heme biosynthesis in human mononuclear cells(51) and HeLa cells(52)
  • as a standard for the quantification of succinylacetone from Plasmodium falciparum cultures(53)

생화학적/생리학적 작용

4,6-Dioxoheptanoic acid is an inhibitor of heme biosynthesis. It is a catabolic byproduct of tyrosine breakdown and inhibits δ-aminolevulinic acid (ALA) dehydratase enzyme. It is a potential marker for detecting tyrosinemia type I and is measured in dried blood spot of new borns.
An inhibitor of heme biosynthesis

관련 제품

제품 번호
설명
가격

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
099M4141V
13181211
019M4055V
019M4056V
13181108

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특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

COA 검색

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

lonp1-dependent Breakdown Of Mitochondrial 5-aminolevulinic Acid Synthase Protein By Heme In Human Liver Cells: 904
Tian Q, et al.
Hepatology, 54(4), 785A-785A (2011)
C M Mak et al.
Hong Kong medical journal = Xianggang yi xue za zhi, 24(4), 340-349 (2018-03-03)
Hereditary channelopathies and cardiomyopathies are potentially lethal and are clinically and genetically heterogeneous, involving at least 90 genes. Genetic testing can provide an accurate diagnosis, guide treatment, and enable cascade screening. The genetic basis among the Hong Kong Chinese population
Hilde Laeremans et al.
JIMD reports, 53(1), 90-102 (2020-05-13)
Nitisinone is used to treat hereditary tyrosinemia type 1 (HT-1) by preventing accumulation of toxic metabolites, including succinylacetone (SA). Accurate quantification of SA during newborn screening is essential, as is quantification of both SA and nitisinone for disease monitoring and
Succinylacetone as primary marker to detect tyrosinemia type I in newborns and its measurement by newborn screening programs
De Jesus V, et al.
Molecular Genetics and Metabolism, 113(1-2), 67-75 (2014)
The effects of levulinic acid and 4, 6-dioxoheptanoic acid on the metabolism of etiolated and greening barley leaves
Meller E and Gassman ML
Plant Physiology, 67(4), 728-732 (1981)
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