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Merck
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주요 문서

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P0300

Sigma-Aldrich

Protein Kinase Inhibitor from rabbit

≥85% (HPLC)

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C94H148N32O31
CAS Number:
99534-03-9
Molecular Weight:
2222.38
MDL number:
MFCD00133989
UNSPSC 코드:
12352200
PubChem Substance ID:
24898093

생물학적 소스

rabbit

분석

≥85% (HPLC)

양식

powder

분자량

2.2 kDa

구성

Peptide content, ≥70%

solubility

water: 1 mg/mL, clear, colorless

저장 온도

−20°C

SMILES string

CCC(C)C(NC(=O)C(C)NC(=O)C(CC(N)=O)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)CNC(=O)C(NC(=O)C(CCCNC(N)=N)NC(=O)CNC(=O)C(CO)NC(=O)C(C)NC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CC(O)=O)NC(=O)C(C)NC(=O)C(Cc2ccc(O)cc2)NC(=O)C(NC(=O)C(N)C(C)O)C(C)O)C(C)CC)C(C)O)C(=O)NC(Cc3cnc[nH]3)C(=O)NC(CC(O)=O)C(O)=O

InChI

1S/C94H148N32O31/c1-11-42(3)70(124-85(150)58(31-50-19-14-13-15-20-50)117-84(149)61(35-67(135)136)116-74(139)44(5)110-81(146)57(32-51-24-26-53(131)27-25-51)119-90(155)73(49(10)130)126-86(151)69(96)47(8)128)88(153)112-45(6)75(140)122-63(40-127)77(142)107-38-65(133)114-55(22-17-29-105-93(99)100)80(145)125-72(48(9)129)87(152)108-39-66(134)113-54(21-16-28-104-92(97)98)78(143)115-56(23-18-30-106-94(101)102)79(144)118-60(34-64(95)132)82(147)111-46(7)76(141)123-71(43(4)12-2)89(154)120-59(33-52-37-103-41-109-52)83(148)121-62(91(156)157)36-68(137)138/h13-15,19-20,24-27,37,41-49,54-63,69-73,127-131H,11-12,16-18,21-23,28-36,38-40,96H2,1-10H3,(H2,95,132)(H,103,109)(H,107,142)(H,108,152)(H,110,146)(H,111,147)(H,112,153)(H,113,134)(H,114,133)(H,115,143)(H,116,139)(H,117,149)(H,118,144)(H,119,155)(H,120,154)(H,121,148)(H,122,140)(H,123,141)(H,124,150)(H,125,145)(H,126,151)(H,135,136)(H,137,138)(H,156,157)(H4,97,98,104)(H4,99,100,105)(H4,101,102,106)

InChI key

AXOXZJJMUVSZQY-UHFFFAOYSA-N

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Amino Acid Sequence

Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp

생화학적/생리학적 작용

Inhibitor of c-AMP-dependent protein kinase
These proteins bind to the catalytic subunit of cyclic-AMP dependent protein kinase, displacing the regulatory subunit and inhibiting phosphorylating activity. The cyclic-AMP binding capacity of the regulatory subunit is enhanced.

특징 및 장점

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number
091M5062V
058K5102
067K5103
089H59694
108H5806

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문서 라이브러리 방문

Z Wang et al.
The Journal of biological chemistry, 273(1), 73-79 (1998-02-07)
Cadmium is mitogenic under some circumstances and has been shown to cause accumulation of transcripts for several proto-oncogenes in a variety of cells, but the mechanism(s) remain to be delineated. Here we show that CdCl2 causes an increase in c-fos
M V Autieri et al.
Cell regulation, 1(13), 1015-1025 (1990-12-01)
We have shown previously that cytoplasmic extracts from actively dividing lymphoid cells are capable of inducing DNA synthesis in isolated nuclei. One of the factors involved in this activity, ADR, appears to be a greater than 90 kDa heat-labile protease.
Li Chen et al.
Food chemistry, 293, 537-544 (2019-06-04)
To verify the effect of protein phosphorylation on glycolysis and elucidate the regulatory mechanism from the perspective of enzyme activity, ovine muscle was treated with a kinase inhibitor, dimethyl sulfoxide, or a phosphatase inhibitor and the activities of glycogen phosphorylase
P Amador et al.
Journal of cellular biochemistry, 101(1), 99-111 (2006-12-21)
Sepsis is a systemic response to infection in which toxins, such as bacterial lipopolysaccharide (LPS), stimulate the production of inflammatory mediators like the cytokine tumor necrosis factor alpha (TNF-alpha). Previous studies from our laboratory have revealed that LPS inhibits the
F O'Rourke et al.
The Biochemical journal, 257(3), 715-721 (1989-02-01)
In contrast with previous reports, it was found that membrane-protein phosphorylation by the catalytic subunit (CS) of cyclic AMP-dependent protein kinase had no effect on Ca2+ uptake into platelet membrane vesicles or on subsequent Ca2+ release by inositol 1,4,5-trisphosphate (IP3).
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