K3761

KT 5720

≥98% (HPLC), powder

• 동의어(들): (9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid hexyl ester
• 실험식(Hill 표기법): C₃₂H₃₁N₃O₅
• CAS Number: 108068-98-0
• Molecular Weight: 537.61
• MDL number: MFCD00132118
• UNSPSC 코드: 51111800
• PubChem Substance ID: 24896235
• NACRES: NA.77

속성

• 생물학적 소스: microbial
• Quality Level: 200
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to faint yellow
• solubility: methanol: 5 mg/mL
• 배송 상태: wet ice
• 저장 온도: −20°C
• SMILES string: CCCCCCOC([C@@]1(O)C[C@@]2([H])N3C(C=CC=C4)=C4C5=C3C6=C(C(C=CC=C7)=C7N6[C@]1(C)O2)C8=C5C(NC8)=O)=O
• InChI: 1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36)/t23-,31+,32-/m0/s1
• InChI key: ZHEHVZXPFVXKEY-IKZDWWSZSA-N

설명

애플리케이션

KT 5720 has been used as a chemical inhibitor of cell signaling pathway. It has also been used as a protein kinase A (PKA) inhibitor to study its effect on the nuclear import of CRTC1 in α-MSH-activated B16-F0 cells and on COX-2 stimulation of tumor-associated Vascular endothelial growth factor (VEGF) expression.

생화학적/생리학적 작용

Specific, cell-permeable inhibitor of protein kinase A (PKA). No significant effect on protein kinase C (PKC), protein kinase G (PKG) or myosin light chain kinase (MLCK).

특징 및 장점

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable