추천 제품
![[Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt ≥95% (HPLC)](/deepweb/assets/sigmaaldrich/product/structures/276/187/9733edf4-6412-4f2b-8cc6-c3f9f3425d4d/640/9733edf4-6412-4f2b-8cc6-c3f9f3425d4d.png)
생물학적 소스
human
Quality Level
분석
≥95% (HPLC)
양식
powder
분자량
2654.2-2660.2 Da
저장 조건
(Keep container tightly closed in a dry and well-ventilated place)
기술
activity assay: suitable
solubility
water: 1.00-1.04 mg/mL, clear, colorless
배송 상태
dry ice
저장 온도
−20°C
SMILES string
S(CC[C@H](N)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCC(=O)N[C@@H](
InChI
1S/C118H202N34O31S2/c1-19-65(14)92(112(179)144-81(54-90(159)160)104(171)145-82(52-63(10)11)114(181)152-46-29-37-86(152)109(176)148-91(64(12)13)111(178)139-72(32-23-24-41-119)97(164)137-74(35-27-44-129-118(125)126)98(165)136-73(34-26-43-128-117(123)124)96(
InChI key
WUYRHUFIUFJVQU-XJUNAYMOSA-N
Amino Acid Sequence
Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala
일반 설명
Research area: Neuroscience
[Gly14]-humanin (HNG) belongs to the family of mitochondrial-derived peptides. HNG (humanin-G) is an analog of humanin, generated by S14G (serine-14-glycine) mutation. HNG shows a 1000 times stronger activity.
[Gly14]-humanin (HNG) belongs to the family of mitochondrial-derived peptides. HNG (humanin-G) is an analog of humanin, generated by S14G (serine-14-glycine) mutation. HNG shows a 1000 times stronger activity.
애플리케이션
[Gly14]-Humanin G human has been used:
- along with bortezomib in pharmacological inhibition studies to treat mice to limit the toxic effects of bortezomib
- to study its effect on high glucose (HG)-induced apoptosis of endothelial cells (ECs)
- to study its neuroprotective effects in an in vitro oxygen-glucose deprivation/reoxygenation (OGD/R) model using SH-SY5Y neuroblastoma cells
[Gly¹⁴]-Humanin G human has been used to limit the toxicity during the bortezomib treatment in neonatal brachial plexus injury (NBPI) mice model. It has also been used in the cell culture of the human-derived neuroblastoma cell line.
생화학적/생리학적 작용
Endogenous rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer′s disease genes and Aβ
Endogenous rescue factor abolishing neuronal cell death by many familial Alzheimer′s disease genes.
[Gly14]-humanin (HNG) stimulates cell growth, proliferation, and cell cycle progression. It enhances proteins such as kinases, transporters, transmembrane receptors, and transcription and translational regulators. HNG exhibits intense in vitro neuroprotective effects compared to natural HN. Studies show that it is an effective cytoprotectant both in vitro and in vivo. HNG is found to prevent high glucose (HG)-induced apoptosis of endothelial cells (ECs). It is proven to inhibit AngII-induced phenotypic switch in vascular smooth muscle cells (VSMCs).
관련 제품
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
Guangsheng Gao et al.
Neurological research, 39(10), 895-903 (2017-07-20)
Humanin (HN) has been identified to suppress neuron death. Gly Rats were randomly divided into 13 groups: Sham group, GI groups and HNG groups. Both GI group and HNG groups included six time points (1, 3, 6, 12, 24, and
Xin Wang et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 110, 248-253 (2018-12-06)
Skin provides the protective barrier for our body and undergoes the continuous regeneration in order to overcome damage from exposure to harmful environments and wounds. Epidermal stem cells (ESCs) play critical roles in skin regeneration. Humanin analogue, S14G-humanin (HNG), a
Qingnian Goh et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(2), e21214-e21214 (2020-11-26)
Neonatal brachial plexus injury (NBPI) causes disabling and incurable contractures, or limb stiffness, which result from proteasome-mediated protein degradation impairing the longitudinal growth of neonatally denervated muscles. We recently showed in a mouse model that the 20S proteasome inhibitor, bortezomib
Yi Xie et al.
Human & experimental toxicology, 41, 9603271221136208-9603271221136208 (2022-10-27)
Angiotensin II (AngII) is involved in the pathogenesis of hypertensive artery remodeling by inducing a phenotypic switch in vascular smooth muscle cells [Gly14]-Humanin (HNG), a humanin analogue, exerts potent cytoprotective effects both in vitro and in vivo. This study aimed
Sia Nikolaou et al.
JCI insight, 4(23) (2019-10-30)
Muscle contractures are a prominent and disabling feature of many neuromuscular disorders, including the 2 most common forms of childhood neurologic dysfunction: neonatal brachial plexus injury (NBPI) and cerebral palsy. There are currently no treatment strategies to directly alter the
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