추천 제품
분석
≥98% (HPLC)
형태
powder
저장 조건
protect from light
색상
white to off-white
solubility
DMSO: >20 mg/mL
저장 온도
2-8°C
SMILES string
OC(=O)\C=C(\CCc1ccc(Cl)cc1)c2ccccc2
InChI
1S/C17H15ClO2/c18-16-10-7-13(8-11-16)6-9-15(12-17(19)20)14-4-2-1-3-5-14/h1-5,7-8,10-12H,6,9H2,(H,19,20)/b15-12-
InChI key
LLJYFDRQFPQGNY-QINSGFPZSA-N
생화학적/생리학적 작용
PS48 is a PDK1 (phosphoinositide-dependent protein kinase 1) activator which binds to the HM/PIF binding pocket rather than the ATP-binding site. PS48 is one of only a few truly allosteric compounds targeting a regulatory binding site on a protein kinase catalytic domain that is not adjacent to or overlapping with the ATP-binding site.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Biology of reproduction, 100(2), 523-534 (2018-08-31)
Spermatogonial stem cells (SSCs) provide the foundation of spermatogenesis. However, because of their small number and slow self-renewal, transfection of SSCs has met with limited success. Although several viral vectors can infect SSCs, genome integration and an inability to maintain
Reversible inhibition of the blood-testis barrier protein improves stem cell homing in mouse testes.
The Journal of reproduction and development, 64(6), 511-522 (2018-09-04)
Stem cell homing is a complex phenomenon that involves multiple steps; thus far, attempts to increase homing efficiency have met with limited success. Spermatogonial stem cells (SSCs) migrate to the niche after microinjection into seminiferous tubules, but the homing efficiency
Pflugers Archiv : European journal of physiology, 468(4), 667-677 (2015-11-19)
Hyperinsulinemia associated with type 2 diabetes may contribute to the development of vascular diseases. Although we recently reported that enhanced contractile responses to serotonin (5-hydroxytryptamine, 5-HT) are observed in the arteries of type 2 diabetes models, the causative factors and
Molecular reproduction and development, 85(4), 290-302 (2018-02-03)
Somatic cell nuclear transfer is a valuable technique for the generation of genetically engineered animals, however, the efficiency of cloning in mammalian species is low (1-3%). Differentiated somatic cells commonly used in nuclear transfer utilize the tricarboxylic acid cycle and
The Journal of arthroplasty, 32(1), 274-279 (2016-08-16)
Increased range of motion to higher degrees of flexion following total knee arthroplasty has been postulated to increase implant damage and revision rates, even in designs modified to accommodate high flexion. We examined posterior-stabilized and high-flexion retrieved tibial inserts to
문서
Sigma-Aldrich offers many products related to phosphoinositide kinases for your research needs.
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