O1877

Ochratoxin A

from Petromyces albertensis, ≥98% (HPLC), powder, mycotoxin

• 동의어(들): N-[(3R)-(5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl]-L-phenylalanine
• 실험식(Hill 표기법): C₂₀H₁₈ClNO₆
• CAS Number: 303-47-9
• Molecular Weight: 403.81
• Beilstein: 1301486
• MDL number: MFCD00078079
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24897954
• NACRES: NA.77

속성

• product name: Ochratoxin A, from Petromyces albertensis, ≥98% (HPLC)
• 생물학적 소스: Petromyces albertensis
• Quality Level: 300
• 분석: ≥98% (HPLC)
• 형태: powder
• 불순물: Benzene, free
• solubility: ethanol: soluble
• 동작 모드: enzyme | inhibits; protein synthesis | interferes
• 저장 온도: 2-8°C
• SMILES string: C[C@@H]1Cc2c(Cl)cc(c(O)c2C(=O)O1)C(=O)N[C@@H](Cc3ccccc3)C(O)=O
• InChI: 1S/C20H18ClNO6/c1-10-7-12-14(21)9-13(17(23)16(12)20(27)28-10)18(24)22-15(19(25)26)8-11-5-3-2-4-6-11/h2-6,9-10,15,23H,7-8H2,1H3,(H,22,24)(H,25,26)/t10-,15+/m1/s1
• InChI key: RWQKHEORZBHNRI-BMIGLBTASA-N

설명

애플리케이션

Ochratoxin A has been used as a mycotoxin:

• to test its effect on metabolism and hypoxia in human embryonic kidney (HEK293) cells
• to test its cytotoxic effects in bovine mammary epithelial cells
• as a standard for gamma radiation studies with food products and in cytotoxic studies using Hep G2 cells

생화학적/생리학적 작용

Ochratoxin A (OTA), a renal toxin, is produced majorly by Aspergillus and Penicillium fungal species. It is immunotoxic, teratogenic myelotoxic, and mutagenic. It effectively interrupts the intestinal barrier functions. OTA displays a long elimination half-life and stimulates the major inflammatory cytokines release.

Ochratoxin A is a mycotoxin found in food that is nephrotoxic and carcinogenic in the kidney and induces differentiation in cloned renal cell lines. Increases endoplasmic reticulum ATP-dependent Ca²⁺ pump activity.

제조 메모

This product is also soluble in chloroform (9.80 - 10.20 mg/ml), methanol (10 mg/ml), ethanol (50 mM), and DMSO (100 mM).

안전성 정보

• 픽토그램: GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H300,H351
• 예방조치 성명서: P201 - P264 - P280 - P301 + P310 + P330 - P308 + P313 - P501
• Hazard Classifications: Acute Tox. 2 Oral - Carc. 2
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges