N6414

NN-DNJ

≥98% (HPLC)

• 실험식(Hill 표기법): C₁₅H₃₁NO₄
• CAS Number: 81117-35-3
• Molecular Weight: 289.41
• MDL number: MFCD00905846
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329818665
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 형태: solid
• solubility: DMSO: >10 mg/mL
• 저장 온도: −20°C
• SMILES string: CCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
• InChI: 1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m1/s1
• InChI key: FTSCEGKYKXESFF-LXTVHRRPSA-N

설명

생화학적/생리학적 작용

NN-DNJ is a glucosidase inhibitor that acts as a pharmacologic chaperone. NN-DNJ also acts synergistically with proteostasis modulators such as celastrol and MG132 to stabilize mutant proteins in properly folded states. NN-DNJ stabilizes various proteins against misfolding, increasing proper trafficking from the endoplasmic reticulum. There is potential use in studying diseases marked by misfolded proteins and has shown antiviral activity.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H319
• 예방조치 성명서: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves