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N1537

Sigma-Aldrich

NU7026

≥98% (HPLC), solid

동의어(들):

2-(Morpholin-4-yl)-benzo[h]chromen-4-one

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About This Item

실험식(Hill 표기법):
C17H15NO3
CAS Number:
154447-35-5
Molecular Weight:
281.31
MDL number:
MFCD06798345
UNSPSC 코드:
12352200
PubChem Substance ID:
329818582
NACRES:
NA.77

Quality Level

100

분석

≥98% (HPLC)

형태

solid

색상

tan

solubility

DMSO: soluble 3 mg/mL at 60 °C
H2O: insoluble

배송 상태

wet ice

저장 온도

2-8°C

SMILES string

O=C1C=C(Oc2c1ccc3ccccc23)N4CCOCC4

InChI

1S/C17H15NO3/c19-15-11-16(18-7-9-20-10-8-18)21-17-13-4-2-1-3-12(13)5-6-14(15)17/h1-6,11H,7-10H2

InChI key

KKTZALUTXUZPSN-UHFFFAOYSA-N

애플리케이션

NU7026 has been used:
  • as a DNA-dependent protein kinase (DNA-PK) inhibitor, to pre-treat colon cancer cell
  • in kinase inhibitor experiments for treating zygotes with visible pronuclei post 20 h-human chorionic gonadotropin (hCG)
  • to determine its influence on cytotoxicity of dibenzo[def,p]chrysene on HepG2 cells

Potent, ATP-competitive. IC50 = 0.23 μM. Selectivity over other PI3K-related kinases (IC50 = 13 μM for PI3K and >100 μM for ATM and ATR).

생화학적/생리학적 작용

Cell permeable, small molecule benzochromenone inhibitor of DNA-PK (DNA dependent protein kinase).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

시험 성적서(COA)

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