N0915

NSC43067

≥98% (HPLC)

• 동의어(들): 1-(5-Methyl-2-thienyl)-3-phenyl-2-Propen-1-one, 1-(5-Methyl-thiophen-2-yl)-3-phenyl-propenone, NSC 43067
• 실험식(Hill 표기법): C₁₄H₁₂OS
• CAS Number: 26903-26-4
• Molecular Weight: 228.31
• MDL number: MFCD00489751
• UNSPSC 코드: 12352202
• PubChem Substance ID: 329818472
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: light yellow to light tan
• solubility: DMSO: >20 mg/mL
• 저장 온도: 2-8°C
• SMILES string: Cc1ccc(s1)C(=O)\C=C\c2ccccc2
• InChI: 1S/C14H12OS/c1-11-7-10-14(16-11)13(15)9-8-12-5-3-2-4-6-12/h2-10H,1H3/b9-8+
• InChI key: AOUMOFQEBZGSPD-CMDGGOBGSA-N

설명

생화학적/생리학적 작용

NSC43067 is a Cyclin-dependent kinase (Cdk) inhibitor which binds to a novel conserved site on Cdk, presumably the p27 binding pocket. The binding apparently directly induces Cdk1, Cdk2, and Cdk4 protein aggregation. Cdks 1, 2, 4, and 6 are the key Cdks that regulate the cell cycle, and are a target for a cancer treatment. NSC43067 arrests the cell cycle at the G0/G1 phase at lower concentrations and at the G2/M cell cycle phase at higher concentrations. The action appears to be reversible.

특징 및 장점

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302,H413
• 예방조치 성명서: P264 - P270 - P273 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 4
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable