추천 제품
생물학적 소스
synthetic (organic)
분석
≥98% (HPLC)
양식
powder
mp
203-204 °C
solubility
acetone: 50 mg/mL, clear to slightly hazy, yellow
SMILES string
O=C(O)C1=CC=CN=C1NC2=CC(C(F)(F)F)=CC=C2
InChI
1S/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,19,20)
InChI key
JZFPYUNJRRFVQU-UHFFFAOYSA-N
유전자 정보
human ... PTGS1(5742)
유사한 제품을 찾으십니까? 방문 제품 비교 안내
애플리케이션
Niflumic acid has been used:
- as a chloride channel blocker in mouse olfactory epithelium for odor-induced electroolfactograms (EOGs) measurements, to test its analgesic effect on rat dorsal root ganglion neurons post γ-aminobutyric acid induction
- as a calcium-activated chloride channel (CaCC) inhibitor in C2C12 myoblasts and also to test its effect on volume-regulated anion channel (VRAC)
- as an inhibitor of voltage-dependent potassium channel in human embryonic kidney (HEK 293) phoenix cells
생화학적/생리학적 작용
Niflumic acid (NFA), a γ-aminobutyric acid type A receptor (GABAARs) antagonist is a non-steroidal anti-inflammatory drug (NSAID) and it belongs to the fenamate class. It is also a blocker of chloride ion channel and a calcium-activated chloride channel (CaCC) inhibitor. NFA possesses anti-inflammatory property and is useful in treating rheumatic disorders. It is also an inhibitor of N-methyl-D-aspartate receptor and glycine receptor. NFA also inhibits enzymes associated with the prostaglandins synthesis.
Selective cyclooxygenase-2 (COX-2) inhibitor.
특징 및 장점
This compound is featured on the Chloride Channels and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Chronic 4
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
개인 보호 장비
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
이미 열람한 고객
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The Journal of general physiology, 140(1), 3-15 (2012-06-27)
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Lingye Chen et al.
The Journal of biological chemistry, 294(39), 14279-14288 (2019-08-08)
Skeletal muscle myoblast differentiation involves elaborate signaling networks, including the activity of various ion channels and transporters. Several K+ and Ca2+ channels have been shown to affect myogenesis, but little is known about roles of Cl- channels in the associated
Tero M Viitanen et al.
Journal of cellular physiology, 228(4), 814-823 (2012-09-29)
The initial step in a synthesis of thyroid hormones is the uptake of iodide from the circulation. Iodide (I(-)) is transported into thyroid cells via a Na(+)/I(-) symporter (NIS), which is electrogenic and thus sensitive to alterations in membrane potential
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