MAK152

Colorimetric Sphingomyelinase Assay Kit

sufficient for 200 colorimetric tests

• 동의어(들): Neutral Sphingomyelinase Assay Kit
• UNSPSC 코드: 12161503
• NACRES: NA.84

속성

• 사용: sufficient for 200 colorimetric tests
• 검출 방법: colorimetric
• 관련 질환(들): rheumatological diseases; cancer
• 저장 온도: −20°C
• 유전자 정보: human ... SMPD2(6610) , SMPD3(55512) , SMPD4(55627) ; mouse ... SMPD2(20598) , SMPD3(58994) , SMPD4(77626) ; rat ... SMPD2(83537) , SMPD3(94338) , SMPD4(303790)

설명

일반 설명

Sphingomyelinase (SMase), or sphingomyelin phosphodiesterase, catalyzes the hydrolytic cleavage of sphingolipid to phosphocholine and ceramide, a second messenger involved in multiple cellular responses including the cellular response to stress. There are at least 5 types of SMases identified which are classified according to their cation dependence, cellular location, and pH optima for activity and include the acidic and neutral sphingomyelinase. Neutral SMases, along with the acidic SMases, are thought to be major contributors to the production of ceramide in response to cellular stress.

특징 및 장점

Compatible with high-throughput handling systems.

적합성

This kit is suitable for the detection of sphingomyelinase activity in a variety of samples such as blood and cell extracts or for screening sphingomyelinase inhibitors and activators.

원리

The Sphingomyelinase Assay Kit provides a simple and direct procedure for measuring neutral SMase activity in a variety of samples such as blood or cell extracts, or for screening SMase activators and inhibitors. SMase activity is determined by a coupled enzyme assay, which results in a colorimetric (655 nm) product proportional to the SMase activity present.

안전성 정보

• 픽토그램: GHS08,GHS05,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H317,H318,H334,H410
• 예방조치 성명서: P261 - P273 - P280 - P302 + P352 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Sens. 1
• Storage Class Code: 10 - Combustible liquids