추천 제품
사용
sufficient for 100 colorimetric or fluorometric tests
검출 방법
colorimetric
fluorometric
관련 질환(들)
rheumatological diseases; gastrointestinal diseases; cardiovascular diseases
저장 온도
−20°C
유전자 정보
human ... XDH(7498)
mouse ... XDH(22436)
rat ... XDH(497811)
일반 설명
Xanthine Oxidase (XO) catalyzes the sequential oxidation of hypoxanthine to xanthine, and xanthine to uric acid and hydrogen peroxide. In humans and other primates, XO controls the final step of purine catabolism and is normally found in the liver and the intestinal mucosa. In rodents, XO is broadly expressed in most tissues. While XO activity is normally very low in blood, liver injury can result in the release of XO into blood. XO may contribute to the pathogenesis of gout and cardiovascular disease, and XO activity or expression may be upregulated in these conditions.
애플리케이션
Xanthine Oxidase Activity Assay Kit has been used to measure the xanthine oxidase in serum samples.
적합성
Suitable for the measurement of xanthine oxidase in a variety of samples including tissue, cells and serum
원리
The Xanthine Oxidase Activity Assay Kit provides a simple and direct procedure for measuring XO activity in a variety of biological samples. XO activity is determined by a coupled enzyme assay, which results in a colorimetric (570 nm)/ fluorometric (λex = 535/λem = 587 nm) product, proportional to the hydrogen peroxide generated. One unit of XO is defined as the amount of enzyme that catalyzes the oxidation of xanthine, yielding 1.0 μmole of uric acid and hydrogen peroxide per minute at 25 °C.
Storage Class Code
10 - Combustible liquids
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시험 성적서(COA)
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이미 열람한 고객
Probiotic therapy alleviates hyperuricemia in C57BL/6 mouse model.
Cao T, et al.
Biomedical Research, 28(5) (2017)
Neelam Malik et al.
International journal of biological macromolecules, 135, 864-876 (2019-06-05)
Xanthine oxidase is an important enzyme of purine catabolism pathway and has been associated directly in pathogenesis of gout and indirectly in many pathological conditions like cancer, diabetes and metabolic syndrome. In this research Hesperidin, a bioactive flavonoid was explored
Anti-gouty arthritis and antihyperuricemia effects of sunflower (Helianthus annuus) head extract in gouty and hyperuricemia animal models.
Li L, et al.
BioMed Research International, 2017, 9-9 (2017)
Neelam Malik et al.
BMC chemistry, 13(1), 53-53 (2019-08-07)
Hesperitin, a naturally occurring flavonoid was hybridized with phenolic acids to evaluate its potential to inhibit the activity of xanthine oxidase (XO), a key enzyme which catalyses xanthine to uric acid which is found to be associated with gout and
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