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Merck
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Key Documents

M5409

Sigma-Aldrich

Mouse IgG2a Isotype Control from murine myeloma

clone UPC-10, purified immunoglobulin, buffered aqueous solution

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.46

생물학적 소스

mouse

Quality Level

항체 형태

purified immunoglobulin

항체 생산 유형

primary antibodies

클론

UPC-10, monoclonal

형태

buffered aqueous solution

기술

flow cytometry: suitable

배송 상태

wet ice

저장 온도

2-8°C

타겟 번역 후 변형

unmodified

관련 카테고리

일반 설명

Immunoglobulin G (IgG) belongs to the immunoglobulin family and is a widely expressed serum antibody. An immunoglobulin has two heavy chains and two light chains connected by a disulfide bond. It is a glycoprotein. IgG is a major class of immunoglobulin. Mouse consists of five immunoglobulin classes- IgM, IgG, IgA, IgD and IgE. Mouse IgG is further divided into five classes- IgG1, IgG2a, IgG2b and IgG3.
Isotype controls are non-reactive immunoglobulins of the same isotype as the primary antibody being used in an application. It is recommended that a non-reactive immunoglobulin of the same isotype and concentration be included as a negative control for each monoclonal antibody reagent used in flow cytometry or other immunoassays.

특이성

When evaluated in flow cytometry, the product did not stain human peripheral blood lymphocytes (PBLs). Anti-Mouse IgG (whole molecule), F(ab′)2 fragment FITC, Catalog Number F2883, along with 1 mg of the product was incubated with human PBLs and then evaluated by flow cytometry.

애플리케이션

Mouse IgG2a Isotype Control from murine myeloma has been used in:
  • immunoprecipitation
  • enzyme-linked immunosorbent assay (ELISA)
  • fluorescence microscopy
  • indirect immunocytochemistry

생화학적/생리학적 작용

Immunoglobulin G (IgG) participates in hypersensitivity type II and type III reactions. It mainly helps in immune defense. IgG helps in opsonization, complement fixation and antibody dependent cell mediated cytotoxicity. IgG2a has cytotropic properties and IgG2 molecules have the ability to activate the complement system.

물리적 형태

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


시험 성적서(COA)

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The Immunoglobulins: Structure and Function, 575-586 (1998)
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Biotechnology and bioengineering, 78(7), 741-752 (2002-05-10)
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Molecular Genetics of Immunoglobulin, 17, 575-586 (1987)

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