모든 사진(1)
About This Item
실험식(Hill 표기법):
C7H12N2S2
CAS Number:
Molecular Weight:
188.31
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
분석
≥98% (HPLC)
양식
powder
색상
off-white to tan
solubility
DMSO: >25 mg/mL
저장 온도
2-8°C
SMILES string
CCC(C)SSc1ncc[nH]1
InChI
1S/C7H12N2S2/c1-3-6(2)10-11-7-8-4-5-9-7/h4-6H,3H2,1-2H3,(H,8,9)
InChI key
BPBPYQWMFCTCNG-UHFFFAOYSA-N
관련 카테고리
애플리케이션
PX 12 has been used as a thioredoxin 1 inhibitor prostate cancer cell lines to analyse its effect on cell viability. It has also been used as a hypoxia-inducible factor (HIF)-1α inhibitor to treat H2228 cells.
생화학적/생리학적 작용
PX 12 is a thioredoxin inhibitor.
PX-12 inhibits the thioredoxin redox system and HIF-1a activity. PX 12 inhibits hypoxia-induced HIF-1a transcriptional activity (IC50 11 nM) and proliferation of HT29 and MCF-7 tumor cells (IC50 1.9 and 0.9 uM, respectively).
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
이미 열람한 고객
EML4-ALK enhances programmed cell death-ligand 1 expression in pulmonary adenocarcinoma via hypoxia-inducible factor (HIF)-1alpha and STAT3
Koh J, et al.
Oncoimmunology, 5(3), e1108514-e1108514 (2016)
Huiwen Ren et al.
Plastic and reconstructive surgery, 142(1), 23e-33e (2018-04-13)
Thioredoxin-1 plays an important role in protecting the skin flap from ischemia-reperfusion injury. Ganoderma lucidum polysaccharide peptide is the major component of G. lucidum, which possesses potent antioxidant and antiapoptotic activity. This study aims to determine whether G. lucidum polysaccharide
Narin Changklungmoa et al.
Parasitology research, 113(6), 2335-2343 (2014-04-11)
In the present study, a cDNA encoding Trx from F. gigantica (FgTrx) was cloned by polymerase chain reaction (PCR). The sequence of FgTrx, analyzed by BLAST, SignalP, and ClustralW programs, showed 315 bp of an open reading frame (ORF), 12 bp 5'UTR
Marissa Opelt et al.
Molecular pharmacology, 93(4), 335-343 (2018-01-24)
According to current views, oxidation of aldehyde dehydrogenase-2 (ALDH2) during glyceryltrinitrate (GTN) biotransformation is essentially involved in vascular nitrate tolerance and explains the dependence of this reaction on added thiols. Using a novel fluorescent intracellular nitric oxide (NO) probe expressed
Thioredoxin-1 protects against androgen receptor-induced redox vulnerability in castration-resistant prostate cancer
Samaranayake GJ, et al.
Nature Communications, 8(1), 1204-1204 (2017)
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