M2518
Menadione sodium bisulfite
BioReagent, suitable for cell culture, ≥95% (TLC)
동의어(들):
2-Methyl-1,4-naphthoquinone sodium bisulfite
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모든 사진(2)
About This Item
실험식(Hill 표기법):
C11H9NaO5S
CAS Number:
Molecular Weight:
276.24
EC Number:
MDL number:
UNSPSC 코드:
12352205
PubChem Substance ID:
NACRES:
NA.75
추천 제품
생물학적 소스
synthetic (organic)
Quality Level
제품 라인
BioReagent
분석
≥95% (TLC)
양식
powder
분자량
Mw 276.24 g/mol
기술
cell culture | mammalian: suitable
cell culture | plant: suitable
색상
white to off-white
solubility
water: soluble 50 mg/mL, clear, colorless to light yellow
저장 온도
−20°C
SMILES string
[Na+].CC1(CC(=O)c2ccccc2C1=O)S([O-])(=O)=O
InChI
1S/C11H10O5S.Na/c1-11(17(14,15)16)6-9(12)7-4-2-3-5-8(7)10(11)13;/h2-5H,6H2,1H3,(H,14,15,16);/q;+1/p-1
InChI key
XDPFHGWVCTXHDX-UHFFFAOYSA-M
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애플리케이션
Menadione sodium bisulfite has been used:
- as a free radical inducer to study its effects on oxidative stress in sunflower seedlings
- as a positive control to produce mitochondrial O2 during the measurement of O2 in human proximal tubular cell lines
- as a redox-cycling mitochondrial pro-oxidant to study its effects on protein kinase B (AKT) and mechanistic target of rapamycin (mTOR) signaling in cardiac cells
생화학적/생리학적 작용
Menadione sodium bisulfite (MSB) is a derivative of vitamin K3 and has been studied in the treatment of hemorrhagic diseases like hypoprothrombinemia and neonatal hemorrhage, caused due to vitamin K3 deficiency. It is also considered a nutritional supplement for animals. MSB shows anticancer effects. It also protects plants from biotic and abiotic stress.
기타 정보
Water soluble vitamin K3.
면책조항
The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
이미 열람한 고객
Y Sanada et al.
Free radical research, 48(8), 919-928 (2014-05-29)
Human oxidation resistance 1 (OXR1) functions in protection against oxidative damage and its homologs are highly conserved in eukaryotes examined so far, but its function still remains uncertain. In this study, we identified a homolog (LMD-3) of human OXR1 in
Kenneth W Olsen et al.
Molecular vision, 17, 270-278 (2011-02-02)
The crystalline lens is a unique cellular organ that performs metabolic processes while maintaining transparency for optical functionality. Mitochondria play a role in providing cells with aerobic respiration necessary for these metabolic processes. Using menadione, a mitochondria-specific inhibitor of the
Dmytro V Gospodaryov et al.
Biochimica et biophysica acta, 1837(11), 1861-1869 (2014-08-16)
An assembled cDNA coding for the putative single-subunit NADH dehydrogenase (NDX) of Ciona intestinalis was introduced into Drosophila melanogaster. The encoded protein was found to localize to mitochondria and to confer rotenone-insensitive substrate oxidation in organello. Transgenic flies exhibited increased
Irina Baran et al.
Cell biochemistry and biophysics, 58(3), 169-179 (2010-08-11)
Menadione (MD) is an effective cytotoxic drug able to produce intracellularly large amounts of superoxide anion. Quercetin (QC), a widely distributed bioflavonoid, can exert both antioxidant and pro-oxidant effects and is known to specifically inhibit cell proliferation and induce apoptosis
Tomokazu Souma et al.
Journal of the American Society of Nephrology : JASN, 22(4), 635-648 (2011-03-05)
A highly acidic environment surrounds proximal tubular cells as a result of their reabsorption of HCO(3)(-). It is unclear whether this luminal acidity affects proteinuria-induced progression of tubular cell damage. Here, we investigated the contribution of luminal acidity to superoxide
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