M2319
Mefloquine hydrochloride
≥98% (HPLC), powder
동의어(들):
(AS)-rel-a-(2R)-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol monohydrochloride
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C17H17ClF6N2O
CAS Number:
Molecular Weight:
414.77
EC Number:
MDL number:
UNSPSC 코드:
12352202
PubChem Substance ID:
NACRES:
NA.77
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
저장 조건
desiccated
색상
white
solubility
DMSO: soluble 38 mg/mL
H2O: insoluble
SMILES string
Cl[H].[H][C@@]1(CCCCN1)[C@@H](O)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F
InChI
1S/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H/t12-,15+;/m1./s1
InChI key
WESWYMRNZNDGBX-YLCXCWDSSA-N
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애플리케이션
Mefloquine hydrochloride has been used:
- to treat cochlear organotypic cultures with various doses to evaluate its role in cellular pathway involved in apoptosis
- in screening for in vitro antischistosomal activity
- in cytotoxicity assay of glioblastoma cells
생화학적/생리학적 작용
Blocker of gap junction channels Cx36 and Cx50.
Mefloquine is broadly used as an antimalarial drug. It inhibits 80S ribosomes of Plasmodium. It has numerous side effects like anxiety, dizziness, tremor, headache, and hearing loss. Mefloquine damages cochlear and vestibular hair cells through apoptosis. It also damages spiral ganglion neurons, degenerates cortical neuron and disrupts neuronal calcium homeostasis.
신호어
Warning
유해 및 위험 성명서
예방조치 성명서
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
이미 열람한 고객
Chanaki Amaratunga et al.
The Lancet. Infectious diseases, 12(11), 851-858 (2012-09-04)
Artemisinin-resistant Plasmodium falciparum has been reported in Pailin, western Cambodia, detected as a slow parasite clearance rate in vivo. Emergence of this phenotype in western Thailand and possibly elsewhere threatens to compromise the effectiveness of all artemisinin-based combination therapies. Parasite
Matshawandile Tukulula et al.
European journal of medicinal chemistry, 57, 259-267 (2012-10-16)
A series of new arylamino quinoline derivatives was designed based on the quinine and mefloquine scaffolds and evaluated in vitro for antiplasmodial and antimycobacterial activities. A number of these compounds exhibited significant activity against the drug-sensitive 3D7 and drug-resistant K1
Regulation of hypoxia-induced autophagy in glioblastoma involves ATG9A
Rahim SAA, et al.
British Journal of Cancer, 117(6), 813-813 (2017)
Sophie Zaloumis et al.
Malaria journal, 11, 303-303 (2012-08-31)
Mechanistic within-host models relating blood anti-malarial drug concentrations with the parasite-time profile help in assessing dosing schedules and partner drugs for new anti-malarial treatments. A comprehensive simulation study to assess the utility of a stage-specific pharmacokinetic-pharmacodynamic (PK-PD) model for predicting
The Plasmodium falciparum cytoplasmic translation apparatus: a promising therapeutic target not yet exploited by clinically approved anti-malarials
Sheridan CM, et al.
Malaria Journal, 17(1), 465-465 (2018)
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