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Merck
모든 사진(1)

주요 문서

G1794

Sigma-Aldrich

GAP-27

≥97% (HPLC)

동의어(들):

Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C60H102N15O17
CAS Number:
198284-64-9
Molecular Weight:
1305.54
MDL number:
MFCD03456920
UNSPSC 코드:
12352202
NACRES:
NA.32

생물학적 소스

human

Quality Level

200

분석

≥97% (HPLC)

형태

powder

포장

pkg of 2 mg

기술

cell culture | mammalian: suitable

solubility

water: soluble 1.00-1.02 mg/mL, clear, colorless

UniProt 수납 번호

P35212

배송 상태

ambient

저장 온도

−20°C

InChI

1S/C60H101N15O17/c1-9-31(4)44(54(86)69-41(29-36-19-13-12-14-20-36)52(84)70-45(32(5)10-2)55(87)72-46(59(91)92)33(6)11-3)71-57(89)48(35(8)78)73-51(83)38(21-15-16-26-61)66-50(82)39(24-25-43(79)80)67-56(88)47(34(7)77)74-53(85)42-23-18-28-75(42)58(90)40(22-17-27-65-60(63)64)68-49(81)37(62)30-76/h12-14,19-20,31-35,37-42,44-48,76-78H,9-11,15-18,21-30,61-62H2,1-8H3,(H,66,82)(H,67,88)(H,68,81)(H,69,86)(H,70,84)(H,71,89)(H,72,87)(H,73,83)(H,74,85)(H,79,80)(H,91,92)(H4,63,64,65)/t31-,32-,33-,34+,35+,37-,38-,39-,40-,41-,42-,44-,45-,46-,47-,48-/m0/s1

InChI key

SXRAPDIXXYFGJG-MDAHIHQXSA-N

유전자 정보

human ... GJA4(2701)

Amino Acid Sequence

Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile

애플리케이션

GAP-27 has been used as a blocking peptide for Cx43 (connexin 43) gap junctions in FDC (follicular dendritic cells)-B cell cultures.

생화학적/생리학적 작용

GAP-27 shares homology with a region of extracellular loops of connexins, and hence, is thought to inhibit junctions formed by the connexins Cx32, Cx40 and Cx43. It highly hinders co-operative cell-cell interactions including the synergized beating of embryonic cardiomyocytes. This peptide reduces osteoclastic activity and survival rates. This peptide significantly reduces acetylcholine-mediated hyperpolarization of smooth muscle cells.
Inhibitor of gap junction signaling in endothelial cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Shaun L Sandow et al.
Circulation research, 90(10), 1108-1113 (2002-06-01)
The nature of the vasodilator endothelium-derived hyperpolarizing factor (EDHF) is controversial, putatively involving diffusible factors and/or electrotonic spread of hyperpolarization generated in the endothelium via myoendothelial gap junctions (MEGJs). In this study, we investigated the relationship between the existence of
Hajnalka Rajnai et al.
Journal of immunology research, 2015, 528098-528098 (2015-03-31)
Follicular dendritic cells (FDC) show homo- and heterocellular metabolic coupling through connexin 43 (Cx43) gap junctions and support B cell selection and maturation in germinal centers. In follicular lymphomas B cells escape apoptosis while FDC develop abnormally. Here we tested
J Ilvesaro et al.
BMC musculoskeletal disorders, 2, 10-10 (2001-12-19)
Bone remodelling is dependent on the balance between bone resorbing osteoclasts and bone forming osteoblasts. We have shown previously that osteoclasts contain gap-junctional protein connexin-43 and that a commonly used gap-junctional inhibitor, heptanol, can inhibit osteoclastic bone resorption. Since heptanol
Wenru Su et al.
Journal of immunology (Baltimore, Md. : 1950), 203(6), 1436-1446 (2019-08-20)
Therapeutic manipulation of regulatory T cells (Tregs) has been regarded as a promising approach for the treatment of immune disorders. However, a better understanding of the immunomodulatory mechanisms of Tregs and new safe and effective methods to improve the therapeutic

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