M2011

Melphalan

powder

• 동의어(들): 4-[Bis(2-chloroethyl)amino]-L-phenylalanine, L-PAM, L-Phenylalanine mustard
• 실험식(Hill 표기법): C₁₃H₁₈Cl₂N₂O₂
• CAS Number: 148-82-3
• Molecular Weight: 305.20
• Beilstein: 2816456
• EC Number: 205-726-3
• MDL number: MFCD00057717
• UNSPSC 코드: 12352207
• PubChem Substance ID: 24278538
• NACRES: NA.32

속성

• 양식: powder
• Quality Level: 200
• 색상: white
• SMILES string: N[C@@H](Cc1ccc(cc1)N(CCCl)CCCl)C(O)=O
• InChI: 1S/C13H18Cl2N2O2/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19/h1-4,12H,5-9,16H2,(H,18,19)/t12-/m0/s1
• InChI key: SGDBTWWWUNNDEQ-LBPRGKRZSA-N

설명

일반 설명

Melphalan also known as L-phenylalanine mustard is an alkylating agent. It belongs to the class of nitrogen mustards, which act as chemotherapeutic agents.

애플리케이션

Melphalan has been used as a drug along with HDAC-inhibitor JNJ-26481585 to treat multiple myeloma (MM) in cell lines and as a chemotherapeutic agent for breast cancer cell line.

생화학적/생리학적 작용

In rat, melphalan in isolated lung perfusion (ILP) functions as a potent therapeutics for sarcomatous pulmonary metastases. It forms DNA intrastrand crosslinks by bifunctional alkylation in 5′-GGC sequences. Melphalan acts as a bone-marrow depressant and is implicated in the treatment of multiple myeloma and ovarian cancer.

Melphalan is an antineoplastic agent.

안전성 정보

• 픽토그램: GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H300,H317,H340,H350,H361
• 예방조치 성명서: P201 - P280 - P301 + P310 + P330 - P302 + P352
• Hazard Classifications: Acute Tox. 2 Oral - Carc. 1A - Muta. 1B - Repr. 2 - Skin Sens. 1
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges