M1275

Naproxen sodium

98.0-102.0%

• 동의어(들): (S)-6-Methoxy-α-methyl-2-naphthaleneacetic acid sodium salt
• 실험식(Hill 표기법): C₁₄H₁₃NaO₃
• CAS Number: 26159-34-2
• Molecular Weight: 252.24
• EC Number: 247-486-2
• MDL number: MFCD00058507
• UNSPSC 코드: 12352200
• PubChem Substance ID: 57654352
• NACRES: NA.77

속성

• 생물학적 소스: synthetic (organic)
• Quality Level: 200
• 분석: 98.0-102.0%
• 형태: powder
• solubility: water: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow
• 주관자: Bayer
• SMILES string: [Na+].COc1ccc2cc(ccc2c1)[C@H](C)C([O-])=O
• InChI: 1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1
• InChI key: CDBRNDSHEYLDJV-FVGYRXGTSA-M
• 유전자 정보: human ... PTGS1(5742) , PTGS2(5743)

설명

일반 설명

Naproxen belongs to phenylacetic acid class of Non-steroidal anti-inflammatory drugs (NSAIDs).

애플리케이션

Naproxen sodium has been used to evaluate the thermodynamics of biomolecular interaction with bovine and human serum albumin. It has also been used to evaluate its efficiency in reducing the response of spinal dorsal horn neurons to noxious knee joint rotation.

생화학적/생리학적 작용

Naproxen binds preferably to serum albumin. The S-enantiomer of naproxen is 28-fold more potential as an anti-inflammatory drug compared to the R-isomer. The R-isomer is found to be a liver toxin and causes gastrointestinal disorders.

Cyclooxygenase (Prostaglandin H synthase 1 and 2) inhibitor.

특징 및 장점

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H302,H360
• 예방조치 성명서: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 1A
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves