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Merck
모든 사진(4)

Key Documents

L0668

Sigma-Aldrich

Anti-LAMP2 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

동의어(들):

Anti-CD107B, Anti-LGP110, Anti-Lysosomal Membrane Glycoprotein-type B (LGP-B), Anti-Lysosome-Associated Membrane Protein 2

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About This Item

MDL number:
UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

rabbit

Quality Level

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

형태

buffered aqueous solution

분자량

antigen ~110 kDa

종 반응성

human (predicted), mouse, rat

기술

indirect immunofluorescence: 10-20 μg/mL using rat NRK and mouse NIH3T3 cells
western blot (chemiluminescent): 2.5-5 μg using whole extract of rat NRK cells

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... LAMP2(3920)
mouse ... Lamp2(16784)
rat ... Lamp2(24944)

일반 설명

LAMP2 (lysosome-associated membrane protein 2) is a heavily glycosylated intrinsic protein (110kD) present in lysosomal membrane. The protein glycosylation is essential for its function to protect the lysosomal membrane from proteolytic enzymes. Anti-LAMP2 antibody can be used in western blotting. It can also be used as a lysosomal marker. Rabbit anti-LAMP2 antibody reacts specifically with LAMP2 of mouse and rat.
Lysosomal associated membrane protein 2 (LAMP2) gene is located on human chromosome Xq24. LAMP2 is majorly expressed in lysosomes. It has three isoforms, that is LAMP2A, LAMP2B and LAMP2C.

면역원

synthetic peptide corresponding to amino acid residues 404-415 of mouse LAMP2 with N-terminal added cysteine, conjugated to KLH. The corresponding sequence is identical in rat and differs by two amino acids in human.

애플리케이션

Anti-LAMP2 antibody can be used in immunofluorescence and immunoblotting
Anti-LAMP2 antibody produced in rabbit has been used in immunohistochemical analysis.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

생화학적/생리학적 작용

Lysosomal associated membrane protein 2 (LAMP2) promotes cell-cell adhesion. It maintains cellular homeostasis and stress.

표적 설명

LAMP2 encodes a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome.

물리적 형태

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


시험 성적서(COA)

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Suraj Dixit et al.
Molecular pharmaceutics, 12(9), 3250-3260 (2015-07-23)
Targeting gold nanoparticles (AuNPs) with two or more receptor binding peptides has been proposed to address intratumoral heterogeneity of glioblastomas that overexpress multiple cell surface receptors to ultimately improve therapeutic efficacy. AuNPs conjugated with peptides against both the epidermal growth
Two human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2, are encoded by genes localized to chromosome 13q34 and chromosome Xq24-25, respectively.
Mattei MG, et al.
The Journal of Biological Chemistry, 265(13), 7548-7551 (1990)
Olga A Mareninova et al.
Cellular and molecular gastroenterology and hepatology, 1(6), 678-694 (2015-12-23)
The pathogenic mechanism of pancreatitis is poorly understood. Recent evidence implicates defective autophagy in pancreatitis responses; however, the pathways mediating impaired autophagy in pancreas remain largely unknown. Here, we investigate the role of lysosome associated membrane proteins (LAMPs) in pancreatitis.
Acute alloxan renal toxicity in the rat initially causes degeneration of thick ascending limbs of Henle
Terayama Y, et al.
Journal of Toxicologic Pathology (2016)
Autoantibodies to hLAMP-2 in ANCA-negative pauci-immune focal necrotizing GN
Peschel A, et al.
Journal of the American Society of Nephrology, 25(3), 455-463 (2014)

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